pseudo steady state hypothesis (PSSH)
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
Related questions
Question
![1. Consider the enzymatic reaction
E+S E S
E.SK E+S
E SE P
ka
PP+ E
E
Here, E represents an enzyme site, S is the reactant, P is the product, and EX is species X bound
to the enzyme site. We consider the species bound to an enzyme site as reactive intermediates.
a) Apply the pseudo steady state hypothesis (PSSH) to E S and solve for [ES] in terms of [E]
and [S].
b) Apply the PSSH to E P and solve for [EP] in terms of [E] and [S].
c)
Show the enzyme site balance. Leave in terms of [E] and [S] (do not try to manipulate the
algebra to solve for [E]).
d)
What is the rate of generation of product P in terms of [E] and [S]?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff5fc9088-6d0a-4312-bffe-77961b56b51f%2F52adab69-f306-46aa-9ad9-e3aaf0e52282%2Fpu19d9j4_processed.jpeg&w=3840&q=75)
Transcribed Image Text:1. Consider the enzymatic reaction
E+S E S
E.SK E+S
E SE P
ka
PP+ E
E
Here, E represents an enzyme site, S is the reactant, P is the product, and EX is species X bound
to the enzyme site. We consider the species bound to an enzyme site as reactive intermediates.
a) Apply the pseudo steady state hypothesis (PSSH) to E S and solve for [ES] in terms of [E]
and [S].
b) Apply the PSSH to E P and solve for [EP] in terms of [E] and [S].
c)
Show the enzyme site balance. Leave in terms of [E] and [S] (do not try to manipulate the
algebra to solve for [E]).
d)
What is the rate of generation of product P in terms of [E] and [S]?
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