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Proteolytic cleavage of GLI, a transcription factor in the Hedgehog pathway, is important to generate GLIR, which enters the nucleus and shuts down transcription of GLI target genes. Which of the following would promote proteolytic cleavage of GLI? O Loss of Sufu Constitutive activation of Smo O Loss of Smo O Loss of Ptch1 receptor O Presence of Hedgehog ligand

Proteolytic cleavage of GLI, a transcription factor in the Hedgehog pathway, is important to generate GLIR, which enters the nucleus and shuts down transcription of GLI target genes. Which of the following would promote proteolytic cleavage of GLI? O Loss of Sufu Constitutive activation of Smo O Loss of Smo O Loss of Ptch1 receptor O Presence of Hedgehog ligand

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Proteolytic cleavage of GLI, a transcription factor in the Hedgehog pathway, is important to generate GLIR, which enters the nucleus and shuts down transcription of GLI target genes. Which of the following would promote proteolytic cleavage of GLI? Loss of Sufu Constitutive activation of Smo O Loss of Smo O Loss of Ptch1 receptor Presence of Hedgehog ligand
Transcribed Image Text:Proteolytic cleavage of GLI, a transcription factor in the Hedgehog pathway, is important to generate GLIR, which enters the nucleus and shuts down transcription of GLI target genes. Which of the following would promote proteolytic cleavage of GLI? Loss of Sufu Constitutive activation of Smo O Loss of Smo O Loss of Ptch1 receptor Presence of Hedgehog ligand
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