Protein A has a binding site for ligand X with a dissociation constant, Kå, of 3.0 × 10-7 M. Protein B has a binding site forligand X with a K₁ of 4.0 × 10-8 M.Calculate the Ka for each protein.Protein A K₂=Protein B K₂=Which protein has greater affinity for ligand X? Why?Protein A has greater affinity because it has a greater Kå than Protein B.Protein B has greater affinity because it has a lower K₂ than Protein A.Protein A has greater affinity because it has a greater Kå than Protein B.O Protein B has greater affinity because it has a lower Kỵ than Protein A.M-1M-1

The higher the value of association constant, the higher the affinity of a protein for a ligand.

Answered: Protein A has a binding site for ligand…

Protein A has a binding site for ligand X with a dissociation constant, Kd, of 3.0 × 10-7 M. Protein B has a binding site for ligand X with a Ka of 4.0 × 10-8 M.

Chemistry

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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Question

Protein A has a binding site for ligand X with a dissociation constant, Kå, of 3.0 × 10-7 M. Protein B has a binding site for
ligand X with a K₁ of 4.0 × 10-8 M.
Calculate the Ka for each protein.
Protein A K₂=
Protein B K₂=
Which protein has greater affinity for ligand X? Why?
Protein A has greater affinity because it has a greater Kå than Protein B.
Protein B has greater affinity because it has a lower K₂ than Protein A.
Protein A has greater affinity because it has a greater Kå than Protein B.
O Protein B has greater affinity because it has a lower Kỵ than Protein A.
M-1
M-1

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