Propose an efficient synthesis for the following transformation: Br + En OH The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A C Mel Br2 Na, NH3 (I) F Br2, H20 H2, Lindlar's catalyst NANH2 H. NaBr, NaOH NaOH Br
Reactive Intermediates
In chemistry, reactive intermediates are termed as short-lived, highly reactive atoms with high energy. They rapidly transform into stable particles during a chemical reaction. In specific cases, by means of matrix isolation and at low-temperature reactive intermediates can be isolated.
Hydride Shift
A hydride shift is a rearrangement of a hydrogen atom in a carbocation that occurs to make the molecule more stable. In organic chemistry, rearrangement of the carbocation is very easily seen. This rearrangement can be because of the movement of a carbocation to attain stability in the compound. Such structural reorganization movement is called a shift within molecules. After the shifting of carbocation over the different carbon then they form structural isomers of the previous existing molecule.
Vinylic Carbocation
A carbocation where the positive charge is on the alkene carbon is known as the vinyl carbocation or vinyl cation. The empirical formula for vinyl cation is C2H3+. In the vinyl carbocation, the positive charge is on the carbon atom with the double bond therefore it is sp hybridized. It is known to be a part of various reactions, for example, electrophilic addition of alkynes and solvolysis as well. It plays the role of a reactive intermediate in these reactions.
Cycloheptatrienyl Cation
It is an aromatic carbocation having a general formula, [C7 H7]+. It is also known as the aromatic tropylium ion. Its name is derived from the molecule tropine, which is a seven membered carbon atom ring. Cycloheptatriene or tropylidene was first synthesized from tropine.
Stability of Vinyl Carbocation
Carbocations are positively charged carbon atoms. It is also known as a carbonium ion.
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![**Title: Efficient Synthesis Process for a Chemical Transformation**
**Objective:**
Propose an efficient synthesis for the following transformation:
**Transformation Overview:**
The structural formula indicates the chemical transformation where an alkyne is being converted to a product with a bromine atom and an alcohol group.
**Question:**
The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as “EBF”). If there is more than one correct solution, provide just one answer.
**Reagents List:**
- **A**: MeI
- **B**: Br₂
- **C**: Na, NH₃ (l)
- **D**: Br₂, H₂O
- **E**: H₂, Lindlar’s catalyst
- **F**: NaNH₂
- **G**: NaBr, NaOH
- **H**: NaOH
- **I**:
**Instructions:**
Based on the provided reagents, determine the correct sequence necessary to achieve the transformation depicted above. Input the correct sequence of letters in the provided box.
**Note:**
Only one correct solution needs to be provided if there are multiple possible answers.
**Please enter your solution below:**
[Text box for input]](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1131871b-8c87-406d-9807-6125c8d6ca38%2F30f91705-a407-493b-a335-195d2dd36258%2Fgbhcblj_processed.jpeg&w=3840&q=75)
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