production, so you look for mutants that make higher amounts of the drug. You identify 16 high producing mutants. You mate haploid mutants 1-6 with haploid mutants 7-12 to produce diploid progeny and the amount of drug produced by the diploid progeny is shown in the Table below (Low indicates wild type quantities, High indicates about 100 times higher than wild type levels. Wild type 7 8 9 10 11 12 Wild type low high low low low low high 1 low high low low low low high 2 low high low high low low high 3 low high low high low low high low high high low high high high low high low high low low high low high low high low low high 5 6

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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2. You identify a fungus that produces low amounts of a
new anti-Covid-19 drug. You want to increase drug
production, so you look for mutants that make higher
amounts of the drug. You identify 16 high producing
mutants. You mate haploid mutants 1-6 with haploid
mutants 7-12 to produce diploid progeny and the amount of
drug produced by the diploid progeny is shown in the Table
below (Low indicates wild type quantities, High indicates
about 100 times higher than wild type levels.
Wild type 7 8 9 10 11 12
high low low low low high
high low low low low high
high low high low low high
high low high low low high
high high low high high high
low high low high low low high
low high low high low low high
Wild type low
1
low
2
low
3
low
low
5
6
(1) Based on the table, as best you can, organized the 16
mutations into complementation groups.
(2) What can you conclude about the wild-type function
of the gene encoded by mutant 1 with respect to rug
production?
(3) What can you conclude about the wild-type function
of the gene encoded by mutant 7
(4) Based on your complementation Table what is the
minimum and maximum number of genes involved in
drug production
(5) Based on your analysis of the complementation Table
how could you potentially increase the production of this
drug beyond 100x?
Transcribed Image Text:2. You identify a fungus that produces low amounts of a new anti-Covid-19 drug. You want to increase drug production, so you look for mutants that make higher amounts of the drug. You identify 16 high producing mutants. You mate haploid mutants 1-6 with haploid mutants 7-12 to produce diploid progeny and the amount of drug produced by the diploid progeny is shown in the Table below (Low indicates wild type quantities, High indicates about 100 times higher than wild type levels. Wild type 7 8 9 10 11 12 high low low low low high high low low low low high high low high low low high high low high low low high high high low high high high low high low high low low high low high low high low low high Wild type low 1 low 2 low 3 low low 5 6 (1) Based on the table, as best you can, organized the 16 mutations into complementation groups. (2) What can you conclude about the wild-type function of the gene encoded by mutant 1 with respect to rug production? (3) What can you conclude about the wild-type function of the gene encoded by mutant 7 (4) Based on your complementation Table what is the minimum and maximum number of genes involved in drug production (5) Based on your analysis of the complementation Table how could you potentially increase the production of this drug beyond 100x?
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