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Problem 1. Fill in the missing products in this synthetic sequence. 1. s-BuLi, THF, -30 C 2. ZnCl2, rt A tBu cat. Pd(OAc)2, P(tBu)3 OMe Br

Problem 1. Fill in the missing products in this synthetic sequence. 1. s-BuLi, THF, -30 C 2. ZnCl2, rt A tBu cat. Pd(OAc)2, P(tBu)3 OMe Br

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1. Fill in the missing products in this synthetic sequence. Problem 2. The following clever sequence of transformations was reported...... Thank you so much

Problem 1. Fill in the missing products in this synthetic sequence. 1. s-BuLi, THF, -30 C 2. ZnCl2, rt Me OTIPS A + RO₂C tBu Problem 2. The following clever sequence of transformations was reported as part of a total synthesis. Provide a mechanism for the first step. For each of the subsequent intermediates, design a short sequence of steps to accomplish the desired transformation. Pay close attention to stereochemistry. OTIPS ہی سے ہے اور OBn Br OMe OH -NBoc Problem 4. Provide the product for each reaction cat. Pd(OAc)2, P(tBu)3 Grubbs' catalyst steps? Me Page < H Problem 3. a. One of the most popular applications of metathesis chemistry is in the synthesis of heterocyclic rings. Design a synthesis of the compound below from acyclic starting materials that uses an olefin metathesis reaction in the key step. Go backward as far as you can, preferably making both C-N bonds. b. This was used in a synthesis of balanol. Complete the synthesis. Ar' steps? OTIPS 1 -NH balanol Ar > of 2 ZOOM +
Transcribed Image Text:Problem 1. Fill in the missing products in this synthetic sequence. 1. s-BuLi, THF, -30 C 2. ZnCl2, rt Me OTIPS A + RO₂C tBu Problem 2. The following clever sequence of transformations was reported as part of a total synthesis. Provide a mechanism for the first step. For each of the subsequent intermediates, design a short sequence of steps to accomplish the desired transformation. Pay close attention to stereochemistry. OTIPS ہی سے ہے اور OBn Br OMe OH -NBoc Problem 4. Provide the product for each reaction cat. Pd(OAc)2, P(tBu)3 Grubbs' catalyst steps? Me Page < H Problem 3. a. One of the most popular applications of metathesis chemistry is in the synthesis of heterocyclic rings. Design a synthesis of the compound below from acyclic starting materials that uses an olefin metathesis reaction in the key step. Go backward as far as you can, preferably making both C-N bonds. b. This was used in a synthesis of balanol. Complete the synthesis. Ar' steps? OTIPS 1 -NH balanol Ar > of 2 ZOOM +
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