Present the rationale of clinical applications of muscarinic receptors antagonists in ophtalmology for refraction testing or for glaucoma treatment.
Present the rationale of clinical applications of muscarinic receptors antagonists in ophtalmology for refraction testing or for glaucoma treatment.
Muscarinic receptors are a class of G-protein coupled receptors (GPCRs). A GPCR is a signal receptor protein so named as it affects the signal transduction through a downstream effector known as G-proteins. G-proteins in turn, activate different pathways.
An agonist is a molecule that activates a receptor, muscarine, and acetylcholine in this case. An antagonist is a substance that prevents receptor activation. Muscarine is not found naturally in the human body but is a metabolite from the mushroom Amanita muscaria.
Acetylcholine is a neurotransmitter, which is a chemical substance released by neurons to transmit nerve impulses. These neurons are also called cholinergic, indicating the neurotransmitter acetylcholine. Cholinergic neurons are found in motor neurons, i.e., neurons that control locomotory muscles, in the brain and the autonomic nervous system.
Glaucoma is an eye condition in which the eye pressure is high, damaging the optic nerve. The two major types of glaucoma are open-angle glaucoma and angle-closure glaucoma.
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