Predict the product and draw the mechanism for the following reaction. H NaOH Draw the mechanism for the following reaction. 1) LDA bat 2)

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Chapter1: Chemical Foundations
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### Transcription and Explanation for Educational Website

#### Reaction 1:

**Instruction:**
- Predict the product and draw the mechanism for the following reaction.

**Reactants:**
- A ketone with the structure: 
```
   O
   ||
CH3-C-CH2-H
```
- Reagent: NaOH

**Explanation:**
- This reaction involves the treatment of an aldehyde with sodium hydroxide (NaOH). 
- It is likely undergoing an aldol condensation, where NaOH acts as a base, creating an enolate ion after deprotonation at the alpha carbon. 
- This enolate ion will then perform a nucleophilic attack on the carbonyl carbon of another aldehyde molecule, forming a β-hydroxy aldehyde (aldol product).
- Upon heating, further dehydration may occur leading to an α,β-unsaturated carbonyl compound.

#### Reaction 2:

**Instruction:**
- Draw the mechanism for the following reaction.

**Reactants:**
- A ketone with the structure:
```
   O
   ||
CH3-C-CH3
```
- Reagents:
  1) LDA (Lithium diisopropylamide)
  2) An ester:
```
   O
   ||
CH3-CH2-O-CH3
```

**Explanation:**
- In this sequence, LDA is a strong, non-nucleophilic base used to generate the enolate ion from the ketone by deprotonating the least hindered alpha hydrogen.
- The generated enolate can then undergo nucleophilic acyl substitution with the ester, forming a β-keto ester or ketone product.
- This reaction sequence could be used to efficiently extend carbon chains or introduce functional groups via a nucleophilic carbon species.

These reactions are fundamental in organic synthesis for forming carbon-carbon bonds, showcasing strategies for building complex molecules from simpler precursors.
Transcribed Image Text:### Transcription and Explanation for Educational Website #### Reaction 1: **Instruction:** - Predict the product and draw the mechanism for the following reaction. **Reactants:** - A ketone with the structure: ``` O || CH3-C-CH2-H ``` - Reagent: NaOH **Explanation:** - This reaction involves the treatment of an aldehyde with sodium hydroxide (NaOH). - It is likely undergoing an aldol condensation, where NaOH acts as a base, creating an enolate ion after deprotonation at the alpha carbon. - This enolate ion will then perform a nucleophilic attack on the carbonyl carbon of another aldehyde molecule, forming a β-hydroxy aldehyde (aldol product). - Upon heating, further dehydration may occur leading to an α,β-unsaturated carbonyl compound. #### Reaction 2: **Instruction:** - Draw the mechanism for the following reaction. **Reactants:** - A ketone with the structure: ``` O || CH3-C-CH3 ``` - Reagents: 1) LDA (Lithium diisopropylamide) 2) An ester: ``` O || CH3-CH2-O-CH3 ``` **Explanation:** - In this sequence, LDA is a strong, non-nucleophilic base used to generate the enolate ion from the ketone by deprotonating the least hindered alpha hydrogen. - The generated enolate can then undergo nucleophilic acyl substitution with the ester, forming a β-keto ester or ketone product. - This reaction sequence could be used to efficiently extend carbon chains or introduce functional groups via a nucleophilic carbon species. These reactions are fundamental in organic synthesis for forming carbon-carbon bonds, showcasing strategies for building complex molecules from simpler precursors.
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