Predict the product A of the first step in the synthesis of Molnupiravir. Propose a mechanism for this reaction. The second step of the synthesis is an esterification reaction. What is the purpose of the first step of this synthesis? H. NH но- ÓH ÓH Uridine

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**Title:** Predicting the Product and Mechanism in the Synthesis of Molnupiravir

**Text:**

Predict the product A of the first step in the synthesis of Molnupiravir. Propose a mechanism for this reaction. The second step of the synthesis is an esterification reaction. What is the purpose of the first step of this synthesis?

**Diagram Explanation:**

1. **Reactants and Conditions:** 
   - Left side of the reaction: Uridine is shown as the starting material with a pyrimidine ring and a ribose sugar having hydroxyl groups.
   - An acid catalyst (H⁺) and an acetic anhydride are used, as indicated by the arrow pointing to the right.

2. **Product A:**
   - The structure shows the acetylation of the hydroxyl groups in the ribose sugar of uridine. The acetyl group is added, resulting in an esterified product.

3. **Molecular Structures:**
   - Uridine is represented on the left with its characteristic cyclic structures.
   - The central step involves acetylation indicated by the molecular structure aligning with acetic anhydride's involvement.
   - The right part of the diagram shows the acetylated sugar moiety of uridine.

**Purpose of the First Step:**

The purpose of the first acetylation step likely includes increasing the compound's stability and/or reactivity by protecting the hydroxyl groups, facilitating a subsequent esterification reaction.
Transcribed Image Text:**Title:** Predicting the Product and Mechanism in the Synthesis of Molnupiravir **Text:** Predict the product A of the first step in the synthesis of Molnupiravir. Propose a mechanism for this reaction. The second step of the synthesis is an esterification reaction. What is the purpose of the first step of this synthesis? **Diagram Explanation:** 1. **Reactants and Conditions:** - Left side of the reaction: Uridine is shown as the starting material with a pyrimidine ring and a ribose sugar having hydroxyl groups. - An acid catalyst (H⁺) and an acetic anhydride are used, as indicated by the arrow pointing to the right. 2. **Product A:** - The structure shows the acetylation of the hydroxyl groups in the ribose sugar of uridine. The acetyl group is added, resulting in an esterified product. 3. **Molecular Structures:** - Uridine is represented on the left with its characteristic cyclic structures. - The central step involves acetylation indicated by the molecular structure aligning with acetic anhydride's involvement. - The right part of the diagram shows the acetylated sugar moiety of uridine. **Purpose of the First Step:** The purpose of the first acetylation step likely includes increasing the compound's stability and/or reactivity by protecting the hydroxyl groups, facilitating a subsequent esterification reaction.
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