Predict the major product of the following reaction: CI H'' H3C Н CH₂CH3 CH3 H3C CI Н но H'' H3C H2C H H3C CH3 CH₂CH3 CH₂CH3 'CH3 Н CH₂CH3 'CH3 Н CH₂CH3 CH3 KOH / heat
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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CI
H"
H3C H
О но
CH₂CH3
CH3
O
H3C
O Cl
H2C
Н
H
H3C Н
I
CH₂CH3
"CH3
CH3
CH₂CH3
CH₂CH3
CH3
H
CH₂CH3
K
H3C CH3
KOH / heat"
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