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Please show me the retrosynthesis and synthesis with detail steps.

Please show me the retrosynthesis and synthesis with detail steps.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Please show me the retrosynthesis and synthesis with detail steps. 

### Formation of an α,β-Unsaturated Carbonyl Compound through Michael Addition #### Reactant Structure: - The left side of the diagram shows a chemical structure with the formula C₉H₁₀O. This is acetophenone, an aromatic ketone where a phenyl group (benzene ring) is attached to a carbonyl group (C=O) and this carbonyl group is further connected to a methyl group (CH₃). ### Reaction Process: - The arrow in the diagram indicates a chemical reaction occurring between the acetophenone (starting material) on the left, and the structure produced on the right side of the diagram. #### Product Structure: - The right side of the diagram shows the resulting α,β-unsaturated carbonyl compound. This product has the following structure: - A phenyl group (benzene ring) is attached to a carbonyl group (C=O). - Next to the carbonyl group, there is a five-membered ring (cyclopentane ring). - The five-membered ring also possesses another carbonyl group (C=O) directly attached to it. - The ring structure and conjugation have formed, suggesting that a cyclization reaction has accompanied the addition, likely a Michael addition followed by an intramolecular aldol condensation. ### Explanation: This reaction demonstrates the formation of an α,β-unsaturated carbonyl compound, evident by the double bond between the alpha (α) and beta (β) positions relative to the carbonyl group. The product's structure implies a mechanism involving an electrophilic addition followed by cyclization to form a more stable ring system. ### Key Concepts: - **Michael Addition**: A nucleophilic conjugate addition of a carbanion or another nucleophile to an α,β-unsaturated carbonyl compound. - **Cyclization**: Intramolecular reactions that form rings, typically resulting in stable cyclic compounds. - **Aromatic Ketone (Acetophenone)**: A compound featuring a benzene ring directly bonded to a carbonyl group. This diagram exemplifies the principles of organic synthesis, showcasing how simple starting materials can react to form more complex structures with desired functionalities through strategic chemical reactions.
Transcribed Image Text:### Formation of an α,β-Unsaturated Carbonyl Compound through Michael Addition #### Reactant Structure: - The left side of the diagram shows a chemical structure with the formula C₉H₁₀O. This is acetophenone, an aromatic ketone where a phenyl group (benzene ring) is attached to a carbonyl group (C=O) and this carbonyl group is further connected to a methyl group (CH₃). ### Reaction Process: - The arrow in the diagram indicates a chemical reaction occurring between the acetophenone (starting material) on the left, and the structure produced on the right side of the diagram. #### Product Structure: - The right side of the diagram shows the resulting α,β-unsaturated carbonyl compound. This product has the following structure: - A phenyl group (benzene ring) is attached to a carbonyl group (C=O). - Next to the carbonyl group, there is a five-membered ring (cyclopentane ring). - The five-membered ring also possesses another carbonyl group (C=O) directly attached to it. - The ring structure and conjugation have formed, suggesting that a cyclization reaction has accompanied the addition, likely a Michael addition followed by an intramolecular aldol condensation. ### Explanation: This reaction demonstrates the formation of an α,β-unsaturated carbonyl compound, evident by the double bond between the alpha (α) and beta (β) positions relative to the carbonyl group. The product's structure implies a mechanism involving an electrophilic addition followed by cyclization to form a more stable ring system. ### Key Concepts: - **Michael Addition**: A nucleophilic conjugate addition of a carbanion or another nucleophile to an α,β-unsaturated carbonyl compound. - **Cyclization**: Intramolecular reactions that form rings, typically resulting in stable cyclic compounds. - **Aromatic Ketone (Acetophenone)**: A compound featuring a benzene ring directly bonded to a carbonyl group. This diagram exemplifies the principles of organic synthesis, showcasing how simple starting materials can react to form more complex structures with desired functionalities through strategic chemical reactions.
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