Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Please provide a balanced equation for the reaction in the picture.
Example of balanced equation format: 2Fe + 3Cl2 = 2FeCl3
Transcribed Image Text:**Scheme 2: Synthesis of Sulfathiazole**
This chemical scheme illustrates the synthesis process for sulfathiazole.
1. **Reactants**:
- **4-acetamidobenzenesulfonyl chloride** is represented with a chemical structure that includes an acetamide group (NHCOCH₃) and a sulfonyl chloride group (SO₂Cl) attached to a benzene ring.
- **2-aminothiazole** is shown with its nitrogen and sulfur-containing heterocyclic ring (thiazole) with an amino group (NH₂) attached.
2. **Reaction Conditions (Step 1)**:
- The reactants are combined in dry acetonitrile (CH₃CN) with potassium carbonate (K₂CO₃) and heated under reflux for 25 minutes.
- This results in the formation of **p-acetamidobenzenesulfonamide**, where the sulfonyl chloride group is converted to a sulfonamide group (SO₂NH).
3. **Reaction Conditions (Step 2)**:
- The intermediate is treated with hydrochloric acid (HCl) and refluxed for an additional 30 minutes.
- This process yields **sulfathiazole**, where the acetamido group is removed, resulting in the final sulfonamide compound with both a benzene ring and a thiazole ring.
Each step of the reaction diagram indicates the transformation of chemical groups, highlighting the reagents and conditions used to achieve the sulfathiazole synthesis.
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