Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. но CoA-S-CH,-c Carboxymethyl-CoA (transition state analog)

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Chapter1: Biochemistry: An Evolving Science
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1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase
and is a proposed transition state analog. Propose a structure for the reaction intermediate
derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with
oxaloacetate.
HOʻ
CoA-S-CH;-C
Carboxymethyl-CoA
(transition state analog)
Transcribed Image Text:Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. HOʻ CoA-S-CH;-C Carboxymethyl-CoA (transition state analog)
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