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Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. но CoA-S-CH,-c Carboxymethyl-CoA (transition state analog)

Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. но CoA-S-CH,-c Carboxymethyl-CoA (transition state analog)

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. HOʻ CoA-S-CH;-C Carboxymethyl-CoA (transition state analog)
Transcribed Image Text:Please post answer with an explanation, thank you! 1. The compound carboxymethyl-CoA (shown below) is a competitive inhibitor of citrate synthase and is a proposed transition state analog. Propose a structure for the reaction intermediate derived from acetyl-COA in the rate-limiting step of the reaction, just prior to its reaction with oxaloacetate. HOʻ CoA-S-CH;-C Carboxymethyl-CoA (transition state analog)
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