Please give the appropriate reagents to complete the following synthesis. 1 HO O O3/DMS Br2/hv O CH3B O AICI3/Cl2 1.. Li 2. Cul O HBr/H2O2 O EtOH O Br2/DCM O AICI3/CH3CI O Cl2/hv
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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1
2
HO
O3/DMS
Br2/hv
CH3B
AICI3/Cl2
1.. Li
2. Cul
HBr/H202
ELOH
Br2/DCM
AICI3/CH3CI
Cl2/hv"
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H2/Pt
MeOH
Grubb's Catalyst
H20
HBr/H20
KMN04
Br2/H20
H2/Pd
HNO3/H2SO4
NaSH, DMSO
NaN3/CH3CN
heat
NaCN, DMF
LDA/DIPA
NBS
HBr/DCM"
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