please explain and show mechanism in detail. thank you Scheme 8. Leahy Asymmetric Synthesis of CBD OMe 1. K₂CO3/ Me₂SO4 1. NaOH / acetone 2. NaBH4 OHC. 3. Savinase/ 2. s-BuLi 3. DMF MeO C5H11 vinyl butyrate 4. NaOH 80% 5 80% DCC/DMAP 28 1. MeLi 2. Grubbs II 31% 26 1. KHMDS toluene CO₂H 2. TMSCI 72% 30 Ar 1. Ph3P=CH₂ 2. MeMgl 24% Ar CO₂H 29 OH 27 98% ee Ar CBD Ar=2,6-(OME)2-4-C5H1₁1

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please explain and show mechanism in detail.
thank you
Scheme 8. Leahy Asymmetric Synthesis of CBD
OMe
1. K₂CO3/
Me₂SO4
1. NaOH / acetone
2. NaBH4
OHC.
2. s-BuLi
3. Savinase/
3. DMF
MeO
C5H11 vinyl butyrate
4. NaOH
80%
5
80%
DCC/DMAP
28
1. MeLi
2. Grubbs II
31%
CO₂H
30
26
1. KHMDS
toluene
2. TMSCI
72%
1. Ph3P=CH2
Ar 2. MeMgl
24%
CO₂H
29
OH
27
98% ee
a
CBD
Ar=2,6-(OME)2-4-C5H11
Ar
Transcribed Image Text:please explain and show mechanism in detail. thank you Scheme 8. Leahy Asymmetric Synthesis of CBD OMe 1. K₂CO3/ Me₂SO4 1. NaOH / acetone 2. NaBH4 OHC. 2. s-BuLi 3. Savinase/ 3. DMF MeO C5H11 vinyl butyrate 4. NaOH 80% 5 80% DCC/DMAP 28 1. MeLi 2. Grubbs II 31% CO₂H 30 26 1. KHMDS toluene 2. TMSCI 72% 1. Ph3P=CH2 Ar 2. MeMgl 24% CO₂H 29 OH 27 98% ee a CBD Ar=2,6-(OME)2-4-C5H11 Ar
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