piligonoal o lo oo i gutwollot 6A. Draw all of the possible aldol addition and condensation products from the following reaction (you may ignore stereochemistry of aldol products but not condensation): NaOH OMe ? H3C CH3 ÓMe

Q: A key step in the synthesis of donepezil is a directed aldol reaction that forms α,β- unsaturated…

A:

Q: Reaction Scheme: 5 CHO NO₂ 6 L-tryptophan H₂O OH do 7 NO₂ Representative procedure for the…

A: The objective of the question is to predict the structure of syn aldol and also explain if…

Q: What is the product formed in the following directed Aldol reaction? НО. OI Oll O III ON O III, IV…

A: Given,The reaction:

Q: Draw the product of nucleophilic substitution with attached neutral nucleophile. When the initial…

A:

Q: Provide the product of the following cross aldol condensation: s H HBr O CF3 H CH₂Cl2

A:

Q: Would this be a reasonable synthesis for (s)-2-benzylcyclohexanone. If not, how can I make it better…

A: (S )- 2 benzylcyclohexanone can be synthesised most effectively by asymmetric synthesis using chiral…

Q: In a mixed aldol addition reaction between these two molecules, which one forms the enolate ion?…

A: We know for enolate ion there must be an acidic proton in the compound .

Q: Propose a mechanism for the aldol reaction below 2 H3C H OH-, H₂O H3C H

A:

Q: 2 H3C ². H OH base H3C H H3C The aldol reaction is a carbonyl condensation reaction between two…

A: The mechanism of given reaction can be explained as:

Q: For the following reaction: H NaOH CH3CH₂OH a Draw the major organic product, assuming no…

A:

Q: Step 1: Add curved arrows. Step 2: The aldehyde is added. Complete the structure and add curved…

A:

Q: Which step in the mechanism of the Aldol condensation reaction of a ketone is the one that makes the…

A: Aldol condensation reaction is a reversible reaction.  Here dilute base NaOH is used to form an…

Q: Draw the enol intermediate and the ketone product formed in the attachedreaction.

A:

Q: For the “crossed” aldol reaction that lead to product C, did the kind of base used make any…

A: Aldol condensation is a very important reaction in organic chemistry. This is a condensation between…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.