Phenylephrine is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl) A) In pharmaceuticals, it is common to coordinate bioactive molecules with either an acid or a base. Here, PE is coordinated with the acid HCl. Draw the structure of PEHCl, being explicit to show which atom in PE accepts the H+ from HCl. B) If the pKa of PEHCl is 5.5, where is PE absorbed: the stomach (pH ≈ 2) or the small intestine (pH ≈ 8)? Provide a brief explanation to support your answer.
Phenylephrine is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl) A) In pharmaceuticals, it is common to coordinate bioactive molecules with either an acid or a base. Here, PE is coordinated with the acid HCl. Draw the structure of PEHCl, being explicit to show which atom in PE accepts the H+ from HCl. B) If the pKa of PEHCl is 5.5, where is PE absorbed: the stomach (pH ≈ 2) or the small intestine (pH ≈ 8)? Provide a brief explanation to support your answer.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Phenylephrine is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl)
A) In pharmaceuticals, it is common to coordinate bioactive molecules with either an acid or a base. Here, PE is coordinated with the acid HCl. Draw the structure of PEHCl, being explicit to show which atom in PE accepts the H+ from HCl.
B) If the pKa of PEHCl is 5.5, where is PE absorbed: the stomach (pH ≈ 2) or the small intestine (pH ≈ 8)? Provide a brief explanation to support your answer.
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