Patlent's serum, antibody content unknown Isolated colony, ldentity unknown Prepared known antigen Antibodles of known Identity Seum Ag Macroscopic reaction Macroscopic reaction Molecular Molecular reaction геaction Ag Ag on microbe Ab (at) In serological diagnosis of disease, a blood sample is tested for the presence of antibody using an antigen of known specificity. A positive reaction Is usually evident as some visible sign, such as color change or clumping, that Indicates a specific Interaction between antibody and antigen. (The reaction at the molecular level is rarely observed.) (b) An unknown microbe is mixed with serum contalning antibodles of known specificity, a procedure known as serotyping. Macroscopic or microscopic clumping Indicates a correct match between antibody and antigen and permits Identification of the microbe. Srep Nneigds ACYwis N.renigda Control Laten Specimen Pesitive (b2) Unknown test colonles from streak plate mixed with antiserum agalnst Nelsserla meningtidis; agglutination on left is positive for that pathogen. ------ ----- Carological diagnosis (hi n

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