3 You are a computational biochemist participating in this international effort. Your project is to identify and investigate the function of the unknown human gene, labeled FABP6. Neither thestructure of the protein for which this gene codes, nor its function, is known. The sequence of the gene was submitted to the sequence database GenBank. GenBank is the NIH geneticsequence database, an annotated collection of all publicly available DNA sequences.Genetic material provides a wealth of information that can provide insight intothe structure and function of the protein it codes during translation. Numerouscomputational methods have been developed to analyze, compare, contrast,and characterize gene and protein sequences. In this case study, you will usea Basic Local Alignment Search Tool (BLAST) sequence alignment andanalysis and information obtained from the Protein Data Bank (PDB) toidentify and investigate the sequence of the unknown gene and the resultingprotein it codes.ORIGIN: Gene sequence1 ТАССGAAАGT GGCCGTТСАА GCTCTАССТС ТСАСТСТТСТ ТААТАСТАСТ САAGTACTТC61 GAGGAACCCT AGAGTCGCTACATTAGCTT TTCCGGGCGT TGAAGTTCTA GCAGTGCCTC121 CACGTCGTCC TACCCGTCCT GAAGTGAACC AGGGTCGTGA TGAGGCCCCC GGTGTGGTACThe Human Genome Project is an international scientific effort with the goalsof determining the sequence of nucleotide base pairs that make up humanDNA and of identifying and mapping all of the genes of the human genome. Itremains the world's largest collaborative biological project. In the USA, theproject launched in 1990 and was declared complete in 2003. Funding camefrom the US government through the National Institutes of Health (NIH),National Science Foundation (NSF), as well as numerous other groups fromaround the world.181 TGGTTGTTCA AGTGACAACC GTТССТТТСG TTGTATGTCТ GTTACCCСGTTCTGCAAGT241 TCCGGTGACACGTCTACСТ СССGCCCТТC GACCAССАСТ ТААAGGGGTT GATAGTGGTC301 TGGAGТСТСТ АGCАСССАСТ GTTCGACCA С СТССАGAGGT GGTGССТССGCACTGGATA361 CTCGCGCACT CGTTCTCTGA CCGGATTCGT CGGTCCGGGC CGGGTCCCTCPart A- Transcription of DNAThe next step in the study of biological systems was to translate the predictedgenes into protein sequences and study the available proteome, the entire setof proteins produced by an organism. This new area of biochemistry wasnamed proteomics. Its goal is a large-scale study of proteins, their structure,and their function. Numerous labs around the world subsequently turned theirefforts to classifying proteins of unknown function by using sequence analysisand similar methods developed by computational biochemists.Transcribe the first 60 nucleotides of DNA (shown below) into its corresponding mRNA sequence.ТАСCGAAAGT GGCCGTTCAA GCTCTACСТС ТСАСТСТТСT ТААТАСТАСТ СААGTACТCEnter the corresponding mRNA sequence.MRNA sequence: AUGGCUUUCA CCGGCAAGUU CGAGAUGGAG AGUGAGAAGA AUUAUGAUGA GUUCAUGAAGSubmitPrevious Answersv CorrectFollowing the transcription of the DNA sequence to its corresponding MRNA sequence, you will now be able to translate it into a polypeptide, or protein.MRNA sequence1 AUGGCUUUCA CCGGCAAGUU CGAGAUGGAG AGUGAGAAGA AUUAUGAUGA GUUCAUGAAG Part G - Disulfide bondsBased on the sequence alignment, is it possible that one or more disulfide bonds exist in this structure? Select the best option to explain why or why not, including the predicted number ofdisulfide bonds.• View Available Hint(s)O Yes, the conserved cysteine and methionine residues will form two disulfide bonds.O No, the residues needed for form a disulfide bond are located too far away from each other in the sequence.O Yes, there are two conserved cysteines in the sequence that might create one disulfide bond.O Yes, there are two conserved methionine residues in the sequence that might create one disulfide bond.O No, functionally important residues needed to form a disulfide bond are not conserved in the alignment.Submit

Name: 3 You are a computational biochemist participating in this internation
Uploaded: 2024-03-20T06:42:55.000Z
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Description: 3 You are a computational biochemist participating in this international effort. Your project is to identify and investigate the function of the unknown human gene, labeled FABP6. Neither thestructure of the protein for which this gene codes, nor its