П Macmill Which carbonyls will give an achiral product after a Grignard reaction with CH,MgBr?

Which carbonyl groups in the anticancer drug Taxol will undergo nucleophilic addition, and which will undergo nucleophilic substitution?

On the synthesis of Product A, was there a notable difference when you used KOH versus LDA as base? Provide a brief explanation. Aldehydes:Butyraldehyde  Bases: KOH, LDA Solvents: Ethanol, Ether Reactions: Butyraldehyde + Ethanol + KOH or LDA Butyraldehyde + Ether + KOH

Synthesize the following compound from cyclohexanone and any other organic and inorganic reagents you need.

Identify the suitable reagents for the given reaction and arrange them accordingly. 1 OH OEt 2 OEt OEt O 1) EtOH, H₂SO4; 2) EtOH, H₂SO4 O 1) EtONa followed by H₂O; 2) TsCl/py followed by EtONa O 1) EtONa followed by H₂O; 2) NaH followed by EtBr O 1) EtOH, H₂SO4; 2) NaH followed by EtBr O 1) EtOH, H₂SO4; 2) TsCy followed by EtONa

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Draw the major organic product of the following reaction sequence

Which of the following compounds will react with methylamine to form the imine shown below? N.

Draw a stepwise mechanism for the following reaction. This reaction combines two processes: the opening of an epoxide ring with a nucleophile and the addition of an electrophile to a carbon–carbon double bond. (Hint: Begin the mechanism by protonating the epoxide ring.)

Coumarin, a naturally occurring compound isolated from lavender, sweet clover, and tonka bean, is made in the laboratory from o-hydroxybenzaldehyde by the reaction depicted below. Draw a stepwise mechanism for this reaction. Coumarin derivatives are useful synthetic anticoagulants.