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Oxygen is transported around the body by the globular protein hemoglobin which contains four Fe2* ions. Hemoglobin is “oxygenated" when coordinated to dissolved oxygen in the blood. This can be simplistically represented by the following equation (where Hb represents one hemoglobin molecule): HЬ (аq) + 40о2 (9) + нь(02)4 (ад) (1) Hemoglobin also readily binds with carbon monoxide (CO). Indeed, hemoglobin has a much higher affinity to CO than O, resulting in significantly stronger hemoglobin binding to CO than to O2. This is a problem because hemoglobin molecules which are coordinated to carbon monoxide are unable to transport oxygen around the body as needed. No more than 2.5% of your body's hemoglobin can be bound to CÓ before health effects become noticeable. The consequence is that even very low partial pressures of CO in the air have physiological implications for humans. нь (ад) + 4Cо (9) + нь(со)4 (аq) (2) Compare and evaluate the relative magnitudes of the equilibrium constant for reaction 1 and reaction 2. The displacement of oxygen bound to haemoglobin with carbon monoxide can be simplistically represented by the following equation: нь02 (ад) + СО (9) + нь(со) (ад) + 02 (9) The equilibrium constant, K, of reaction 3 is ~200 at body temperature. If the ratio [HBCO]/[HbO2] approaches 1, death is probable for humans. Calculate the partial pressure of CO (g) in the air (at equilibrium) that is likely to be fatal? Assume the partial pressure of O2 (g) is 0.20 atm. Hint: Write the equilibrium constant expression for the new reaction presented above. Are there expressions that we can cancel/neglect?

Oxygen is transported around the body by the globular protein hemoglobin which contains four Fe2* ions. Hemoglobin is “oxygenated" when coordinated to dissolved oxygen in the blood. This can be simplistically represented by the following equation (where Hb represents one hemoglobin molecule): HЬ (аq) + 40о2 (9) + нь(02)4 (ад) (1) Hemoglobin also readily binds with carbon monoxide (CO). Indeed, hemoglobin has a much higher affinity to CO than O, resulting in significantly stronger hemoglobin binding to CO than to O2. This is a problem because hemoglobin molecules which are coordinated to carbon monoxide are unable to transport oxygen around the body as needed. No more than 2.5% of your body's hemoglobin can be bound to CÓ before health effects become noticeable. The consequence is that even very low partial pressures of CO in the air have physiological implications for humans. нь (ад) + 4Cо (9) + нь(со)4 (аq) (2) Compare and evaluate the relative magnitudes of the equilibrium constant for reaction 1 and reaction 2. The displacement of oxygen bound to haemoglobin with carbon monoxide can be simplistically represented by the following equation: нь02 (ад) + СО (9) + нь(со) (ад) + 02 (9) The equilibrium constant, K, of reaction 3 is ~200 at body temperature. If the ratio [HBCO]/[HbO2] approaches 1, death is probable for humans. Calculate the partial pressure of CO (g) in the air (at equilibrium) that is likely to be fatal? Assume the partial pressure of O2 (g) is 0.20 atm. Hint: Write the equilibrium constant expression for the new reaction presented above. Are there expressions that we can cancel/neglect?

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Oxygen is transported around the body by the globular protein hemoglobin which contains four Fe2* ions. Hemoglobin is “oxygenated" when coordinated to dissolved oxygen in the blood. This can be simplistically represented by the following equation (where Hb represents one hemoglobin molecule): н (ад) + 402 (д) + нь(02)4 (аq) (1) Hemoglobin also readily binds with carbon monoxide (CO). Indeed, hemoglobin has a much higher affinity to CO than O2 resulting in significantly stronger hemoglobin binding to CO than to O2. This is a problem because hemoglobin molecules which are coordinated to carbon monoxide are unable to transport oxygen around the body as needed. No more than 2.5% of your body's hemoglobin can be bound to CO before health effects become noticeable. The consequence is that even very low partial pressures of CO in the air have physiological implications for humans. нь (ад) + 4Cо (д) + нь(со)4 (аq) (2) Compare and evaluate the relative magnitudes of the equilibrium constant for reaction 1 and reaction 2. The displacement of oxygen bound to haemoglobin with carbon monoxide can be simplistically represented by the following equation: нь02 (ад) + Со (9) + нь(со) (ад) + 02 (9) The equilibrium constant, K, of reaction 3 is ~200 at body temperature. If the ratio [HBCO]/[HbO2] approaches 1, death is probable for humans. Calculate the partial pressure of CO (g) in the air (at equilibrium) that is likely to be fatal? Assume the partial pressure of O2 (g) is 0.20 atm. Hint: Write the equilibrium constant expression for the new reaction presented above. Are there expressions that we can cancel/neglect?
Transcribed Image Text:Oxygen is transported around the body by the globular protein hemoglobin which contains four Fe2* ions. Hemoglobin is “oxygenated" when coordinated to dissolved oxygen in the blood. This can be simplistically represented by the following equation (where Hb represents one hemoglobin molecule): н (ад) + 402 (д) + нь(02)4 (аq) (1) Hemoglobin also readily binds with carbon monoxide (CO). Indeed, hemoglobin has a much higher affinity to CO than O2 resulting in significantly stronger hemoglobin binding to CO than to O2. This is a problem because hemoglobin molecules which are coordinated to carbon monoxide are unable to transport oxygen around the body as needed. No more than 2.5% of your body's hemoglobin can be bound to CO before health effects become noticeable. The consequence is that even very low partial pressures of CO in the air have physiological implications for humans. нь (ад) + 4Cо (д) + нь(со)4 (аq) (2) Compare and evaluate the relative magnitudes of the equilibrium constant for reaction 1 and reaction 2. The displacement of oxygen bound to haemoglobin with carbon monoxide can be simplistically represented by the following equation: нь02 (ад) + Со (9) + нь(со) (ад) + 02 (9) The equilibrium constant, K, of reaction 3 is ~200 at body temperature. If the ratio [HBCO]/[HbO2] approaches 1, death is probable for humans. Calculate the partial pressure of CO (g) in the air (at equilibrium) that is likely to be fatal? Assume the partial pressure of O2 (g) is 0.20 atm. Hint: Write the equilibrium constant expression for the new reaction presented above. Are there expressions that we can cancel/neglect?
Why is it important that the value of the equilibrium constant K for hemoglobin binding to oxygen is small (ideally close to 1)? What would be the consequence if K for this equilibrium was 10 times larger? Hint: What does it mean when the K value is equal to 1? How does this relate to the function (or functions) of the hemoglobin inside our body?
Transcribed Image Text:Why is it important that the value of the equilibrium constant K for hemoglobin binding to oxygen is small (ideally close to 1)? What would be the consequence if K for this equilibrium was 10 times larger? Hint: What does it mean when the K value is equal to 1? How does this relate to the function (or functions) of the hemoglobin inside our body?
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