One approach to find approximate matches is to use a strategy known as filtration. What is the basic logic of filtration? Filtration removes all of the areas of the sequences that do not overlap to reduce computational time. Filtration refers to the practice of drinking a cup of filtered coffee before trying to find approximate matches. The caffeine from the filtered coffee helps us remember the correct answer. A pair of sequences will share multiple k-mers that can be used to seed the alignment.

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