A synthon is a concept in retrosynthetic analysis. It is defined as a structural unit within amolecule which is related to a possible synthetic operation.Example:OHbond breaks heresynthesisBr+retrosynthesisNEC Na -NaBrSynthonsC-C bond formationsynthetic equivalentsBrD=00CNOH||ⒸC=NH₂O, H+hydrolysisdo not existexistfunctional group transformationCommon synthons:C1 synthons: carbon dioxide, carbon monoxide, cyanide, formaldehyde C2synthons: acetylene, acetaldehydeC₂H4OH synthon: ethylene oxideOHCarbocation synthons: alkyl halides, carbonyl CCarbanion synthons: Grignard reagents, organolithiums, malonic ester/acetoacetic ester, terminalalkyneUse the synthons listed above, propose how you would synthesis the following molecules: НО

The question is based on the concept of organic synthesis.We need to synthesize the product using…

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Chemistry

ОН

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

A synthon is a concept in retrosynthetic analysis. It is defined as a structural unit within a
molecule which is related to a possible synthetic operation.
Example:
OH
bond breaks here
synthesis
Br
+
retrosynthesis
NEC Na -NaBr
Synthons
C-C bond formation
synthetic equivalents
Br
D=00
CN
OH
||
ⒸC=N
H₂O, H+
hydrolysis
do not exist
exist
functional group transformation
Common synthons:
C1 synthons: carbon dioxide, carbon monoxide, cyanide, formaldehyde C2
synthons: acetylene, acetaldehyde
C₂H4OH synthon: ethylene oxide
OH
Carbocation synthons: alkyl halides, carbonyl C
Carbanion synthons: Grignard reagents, organolithiums, malonic ester/acetoacetic ester, terminal
alkyne
Use the synthons listed above, propose how you would synthesis the following molecules:

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