ollowing is an outline for a synthesis of the anorexic (appetite suppressant) fenflura- mine. This compound was one of the two ingredients in Phen-Fen, a weight-loss prep- aration now banned because of its potential to cause irreversible heart valve damage. N-OH `NH2 CF3 CF3 CF3 CF3 `CF3 CF3 Fenfluramine

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Chapter1: Chemical Foundations
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Propose reagents and conditions for Step 1. Account for the fact that the CF3 group is meta directing.

ollowing is an outline for a synthesis of the anorexic (appetite suppressant) fenflura-
mine. This compound was one of the two ingredients in Phen-Fen, a weight-loss prep-
aration now banned because of its potential to cause irreversible heart valve damage.
N-OH
`NH2
CF3
CF3
CF3
CF3
`CF3
CF3
Fenfluramine
Transcribed Image Text:ollowing is an outline for a synthesis of the anorexic (appetite suppressant) fenflura- mine. This compound was one of the two ingredients in Phen-Fen, a weight-loss prep- aration now banned because of its potential to cause irreversible heart valve damage. N-OH `NH2 CF3 CF3 CF3 CF3 `CF3 CF3 Fenfluramine
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