OH OH PBr3 Mg MgBr yo Br CH2CI2 ether 2. H20

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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The image illustrates a chemical synthesis process involving several reaction steps:

1. **Starting Material:**
   - The process begins with an alcohol, specifically tert-butyl alcohol, depicted as (CH₃)₃COH.

2. **Conversion to Alkyl Bromide:**
   - The alcohol is treated with phosphorus tribromide (PBr₃) in a dichloromethane (CH₂Cl₂) solvent. This converts the alcohol into tert-butyl bromide, represented as (CH₃)₃CBr.

3. **Formation of Grignard Reagent:**
   - The alkyl bromide undergoes a reaction with magnesium (Mg) in an ether solvent, forming a Grignard reagent, tert-butylmagnesium bromide ((CH₃)₃CMgBr).

4. **Reaction with an Aldehyde:**
   - The Grignard reagent then reacts with acetaldehyde (CH₃CHO) in a two-step process:
     - Step 1 involves the addition of the Grignard reagent to the carbonyl group.
     - Step 2 involves a hydrolysis reaction with water (H₂O) to form the final product.

5. **Final Product:**
   - The final compound is a secondary alcohol, 2-methyl-2-butanol, depicted as (CH₃)₃CCH(OH)CH₃.

This sequence demonstrates a classic application of Grignard reagents in organic synthesis, allowing the formation of new carbon-carbon bonds.
Transcribed Image Text:The image illustrates a chemical synthesis process involving several reaction steps: 1. **Starting Material:** - The process begins with an alcohol, specifically tert-butyl alcohol, depicted as (CH₃)₃COH. 2. **Conversion to Alkyl Bromide:** - The alcohol is treated with phosphorus tribromide (PBr₃) in a dichloromethane (CH₂Cl₂) solvent. This converts the alcohol into tert-butyl bromide, represented as (CH₃)₃CBr. 3. **Formation of Grignard Reagent:** - The alkyl bromide undergoes a reaction with magnesium (Mg) in an ether solvent, forming a Grignard reagent, tert-butylmagnesium bromide ((CH₃)₃CMgBr). 4. **Reaction with an Aldehyde:** - The Grignard reagent then reacts with acetaldehyde (CH₃CHO) in a two-step process: - Step 1 involves the addition of the Grignard reagent to the carbonyl group. - Step 2 involves a hydrolysis reaction with water (H₂O) to form the final product. 5. **Final Product:** - The final compound is a secondary alcohol, 2-methyl-2-butanol, depicted as (CH₃)₃CCH(OH)CH₃. This sequence demonstrates a classic application of Grignard reagents in organic synthesis, allowing the formation of new carbon-carbon bonds.
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