OEt 1. NaCN 2. H3O* quench HO" 1. SOCI2 2. NaSH NaH OH 1. TSCI, pyridine 2. NaOEt, EtOH

Chemistry
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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Spiderweb chemistry . Reagents needed to get the major product and show stereochemistry.

This image illustrates a sequence of chemical reactions, highlighting the transformation of alcohols using various reagents:

### Reaction Pathway 1:
1. **Starting Material:** Secondary alcohol on a cyclohexane ring.
2. **Reagents Used:** 
   - 1. **TsCl, Pyridine**
   - 2. **NaOEt, EtOH**
3. **Intermediate Products:** Tosylate formation followed by elimination to form an alkene.
4. **Final Product:** 1-hexene with a double bond.

### Reaction Pathway 2:
1. **Starting Material:** Epoxide with a cyclopentane ring.
2. **Reagents Used:**
   - 1. **NaCN**
   - 2. **H₃O⁺ quench**
3. **Intermediate Products:** Nitrile formation followed by hydrolysis.
4. **Reagents Used for Further Transformation:** 
   - **NaH**
5. **Further Reaction:**
   - 1. **SOCl₂**
   - 2. **NaSH**
6. **Final Product:** Transforms to a thiol derivative (not explicitly shown in text).

### Explanation:
- The reactions showcase typical functional group interconversions used in organic synthesis, like the conversion of alcohols to tosylates for elimination reactions and the transformation of epoxides to other functional groups.
- **NaCN & H₃O⁺:** Convert epoxides to nitriles.
- **SOCl₂ & NaSH:** Transform epoxides into thiol derivatives.

Such transformations are vital in organic synthesis for building complex molecules from simpler starting materials.
Transcribed Image Text:This image illustrates a sequence of chemical reactions, highlighting the transformation of alcohols using various reagents: ### Reaction Pathway 1: 1. **Starting Material:** Secondary alcohol on a cyclohexane ring. 2. **Reagents Used:** - 1. **TsCl, Pyridine** - 2. **NaOEt, EtOH** 3. **Intermediate Products:** Tosylate formation followed by elimination to form an alkene. 4. **Final Product:** 1-hexene with a double bond. ### Reaction Pathway 2: 1. **Starting Material:** Epoxide with a cyclopentane ring. 2. **Reagents Used:** - 1. **NaCN** - 2. **H₃O⁺ quench** 3. **Intermediate Products:** Nitrile formation followed by hydrolysis. 4. **Reagents Used for Further Transformation:** - **NaH** 5. **Further Reaction:** - 1. **SOCl₂** - 2. **NaSH** 6. **Final Product:** Transforms to a thiol derivative (not explicitly shown in text). ### Explanation: - The reactions showcase typical functional group interconversions used in organic synthesis, like the conversion of alcohols to tosylates for elimination reactions and the transformation of epoxides to other functional groups. - **NaCN & H₃O⁺:** Convert epoxides to nitriles. - **SOCl₂ & NaSH:** Transform epoxides into thiol derivatives. Such transformations are vital in organic synthesis for building complex molecules from simpler starting materials.
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