O Which is the most stable chair conformer of the following compound? EM NH NH NH₂ D. A. B. A D B C.

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### Stability of Chair Conformations

**Question:**
Which is the most stable chair conformer of the following compound?

**Images of Conformers:**
- A representation of the compound is shown, which appears to be a substituted cyclohexane with a nitrogen atom.
- Four possible chair conformers of this compound are presented as A, B, C, and D.

**Conformers:**
- **A.** First chair form
- **B.** Second chair form
- **C.** Third chair form
- **D.** Fourth chair form

**Answer Options:**
- ⃝ A
- ⃝ D
- ⃝ B
- ⃝ C

**Graph/Diagram Explainations:**
The provided diagram shows four distinct chair conformations of a substituted cyclohexane:

A. The first chair conformation displays the substituent in an axial position.
B. The second chair conformation places the substituent in an equatorial position.
C. The third chair conformation mirrors the substituent in a different axial position.
D. The fourth chair conformation shows the substituent in another equatorial position and some steric hindrance minimization.

**Note:**
The stability of chair conformers depends on the position of the substituent groups. Typically, substituents prefer the equatorial position to minimize 1,3-diaxial interactions, making the chair conformer with the equatorial substituent the most stable one.

Proceed with selecting the most stable conformer based on these principles.
Transcribed Image Text:### Stability of Chair Conformations **Question:** Which is the most stable chair conformer of the following compound? **Images of Conformers:** - A representation of the compound is shown, which appears to be a substituted cyclohexane with a nitrogen atom. - Four possible chair conformers of this compound are presented as A, B, C, and D. **Conformers:** - **A.** First chair form - **B.** Second chair form - **C.** Third chair form - **D.** Fourth chair form **Answer Options:** - ⃝ A - ⃝ D - ⃝ B - ⃝ C **Graph/Diagram Explainations:** The provided diagram shows four distinct chair conformations of a substituted cyclohexane: A. The first chair conformation displays the substituent in an axial position. B. The second chair conformation places the substituent in an equatorial position. C. The third chair conformation mirrors the substituent in a different axial position. D. The fourth chair conformation shows the substituent in another equatorial position and some steric hindrance minimization. **Note:** The stability of chair conformers depends on the position of the substituent groups. Typically, substituents prefer the equatorial position to minimize 1,3-diaxial interactions, making the chair conformer with the equatorial substituent the most stable one. Proceed with selecting the most stable conformer based on these principles.
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