Nucleus Cytoplasm Neuron -PrpSc -PrpC A prion protein in the PrpSc conformation comes in contact with a PrpC protein, converting it into a PrpSc protein. - Original PrpSc molecule -PrpSc converted from PrpC The 2 PrpSc proteins bind to 2 PrpC proteins, and convert them to PrpSc Over time, all of the PrpC proteins will be converted to PrpSc proteins. FIGURE 25.9 A proposed molecular mechanism of prion diseases. The PrPSc protein catalyzes the conver- sion of a PrP protein to PrP8*. Over time, the PIPS conformation accumulates to high levels, leading to ONLINE ANIMATION symptoms of the prion disease.
Nucleus Cytoplasm Neuron -PrpSc -PrpC A prion protein in the PrpSc conformation comes in contact with a PrpC protein, converting it into a PrpSc protein. - Original PrpSc molecule -PrpSc converted from PrpC The 2 PrpSc proteins bind to 2 PrpC proteins, and convert them to PrpSc Over time, all of the PrpC proteins will be converted to PrpSc proteins. FIGURE 25.9 A proposed molecular mechanism of prion diseases. The PrPSc protein catalyzes the conver- sion of a PrP protein to PrP8*. Over time, the PIPS conformation accumulates to high levels, leading to ONLINE ANIMATION symptoms of the prion disease.
Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter3: The Cellular Level Of Organization
Section: Chapter Questions
Problem 6RQ: Because they are embedded within the membrane, ion channels are examples of ________. receptor...
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Question
Where does the prion protein come from?
![Nucleus
Cytoplasm
Neuron
-PrpSc
-PrpC
A prion protein in the PrpSc
conformation comes in contact
with a PrpC protein, converting it
into a PrpSc protein.
- Original PrpSc
molecule
-PrpSc
converted
from PrpC](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8fae91e2-3e5b-4e40-8d9e-2ecc1bc2f3dd%2F1d1abf76-8a52-4a17-b85a-2e3995c3170e%2Fhzicdps.png&w=3840&q=75)
Transcribed Image Text:Nucleus
Cytoplasm
Neuron
-PrpSc
-PrpC
A prion protein in the PrpSc
conformation comes in contact
with a PrpC protein, converting it
into a PrpSc protein.
- Original PrpSc
molecule
-PrpSc
converted
from PrpC
![The 2 PrpSc proteins bind
to 2 PrpC proteins, and
convert them to PrpSc
Over time, all of the PrpC
proteins will be converted
to PrpSc proteins.
FIGURE 25.9 A proposed molecular mechanism
of prion diseases. The PrPSc protein catalyzes the conver-
sion of a PrP protein to PrP8*. Over time, the PIPS
conformation accumulates to high levels, leading to
ONLINE
ANIMATION
symptoms of the prion disease.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8fae91e2-3e5b-4e40-8d9e-2ecc1bc2f3dd%2F1d1abf76-8a52-4a17-b85a-2e3995c3170e%2Fzy82lho.png&w=3840&q=75)
Transcribed Image Text:The 2 PrpSc proteins bind
to 2 PrpC proteins, and
convert them to PrpSc
Over time, all of the PrpC
proteins will be converted
to PrpSc proteins.
FIGURE 25.9 A proposed molecular mechanism
of prion diseases. The PrPSc protein catalyzes the conver-
sion of a PrP protein to PrP8*. Over time, the PIPS
conformation accumulates to high levels, leading to
ONLINE
ANIMATION
symptoms of the prion disease.
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