Now you know that nitrite cause the formation of methemoglobin. Then our question is actually: "Wh does methemoglobin cause cyanosis as if not enough oxygen was delivered to cells?"
Now you know that nitrite cause the formation of methemoglobin. Then our question is actually: "Wh does methemoglobin cause cyanosis as if not enough oxygen was delivered to cells?"
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
Problem 1SRQ
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Can you please help answer this question?
Transcribed Image Text:A BCH 110A –- Homework 4 -W21-Hb and Enzymes Introduction.pdf (page 1 of 6)
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BCH 110A - Homework 4 -W21- Hb and Enzymes Introduction.pdf (page 1 of 6)
all HbF is substituted for adult hemoglobin, the baby is hematologically an adult.
4) Infants are deficient of certain enzymes that keep the iron in the reduced state during the first
several months of life.
Now you know that nitrite cause the formation of methemoglobin. Then our question is actually: "Why
does methemoglobin cause cyanosis as if not enough oxygen was delivered to cells?"
Structurally methemoglobin is equivalent to oxyhemoglobin. It has instead oxygen water bound.
Hint: Shown to the right is the situation in which half of
Fe(II) got oxidized to Fe(III). The pressure of oxygen in
arterial blood is about 100 mm Hg and in the veins 35 mm
Hg.
1.0
Hb
0.8-
Met-Hb
Y 06
04
0.2
20
40
60
80
100
P/mm Hg
![BCH 110A - Hormework 4 -W21- Hb and Enzymes Introduction.pdf (page 1 of 6)
1. Why is nitrate contaminated water so dangerous to newborns?
Although nitrate is quite harmless to an adult, it is quite dangerous to newborns causing even at low
concentration cyanosis due to oxidation of Fe(II) heme to Fe(III) heme (i.e., hemoglobin to
methemoglobin) [Cyanosis is a bluish discoloration of the skin and mucous membranes.]
The real culprit the nitrite. The infant's increased susceptibility to nitrate, is due several factors.
1) Relative to their size, infant consumes 10 times as much water as an adult,
2) The elevated pH of its intestines encourages the growth of bacteria that reduce nitrate to nitrite.
3) Fetal hemoglobin (HbF) is more sensitive to oxidizing chemicals such as the nitrite ion. As the
concentration of HbF decreases, so does the susceptibility to nitrite. By the end of the first year
all HbF is substituted for adult hemoglobin, the baby is hematologically an adult.
4) Infants are deficient of certain enzymes that keep the iron in the reduced state during the first
several months of life.
Now you know that nitrite cause the formation of methemoglobin. Then our question is actually: "Why
does methemoglobin cause cyanosis as if not enough oxygen was delivered to cells?"
Structurally methemoglobin is equivalent to oxyhemoglobin. It has instead oxygen water bound.
Hint: Shown to the right is the situation in which half of
Fe(II) got oxidized to Fe(III). The pressure of oxygen in
arterial blood is about 100 mm Hg and in the veins 35 mm
Hg.
1.0
Hb
0.8 -
Met-Hb
Y 06
04
F, 2/18- The Spanish Voyages of Exploration, 1492-1522
MacBook Air
80
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םםב
4)
F5
F6
F7
F8
F9
F10
&
4.
5
7
8
9
T.
Y
U
P
< 6](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcaf61854-7522-4075-8af1-447956fb28ae%2Fcfefb9ab-d9ae-48f7-9211-5967818652e3%2Fs4z7zj_processed.jpeg&w=3840&q=75)
Transcribed Image Text:BCH 110A - Hormework 4 -W21- Hb and Enzymes Introduction.pdf (page 1 of 6)
1. Why is nitrate contaminated water so dangerous to newborns?
Although nitrate is quite harmless to an adult, it is quite dangerous to newborns causing even at low
concentration cyanosis due to oxidation of Fe(II) heme to Fe(III) heme (i.e., hemoglobin to
methemoglobin) [Cyanosis is a bluish discoloration of the skin and mucous membranes.]
The real culprit the nitrite. The infant's increased susceptibility to nitrate, is due several factors.
1) Relative to their size, infant consumes 10 times as much water as an adult,
2) The elevated pH of its intestines encourages the growth of bacteria that reduce nitrate to nitrite.
3) Fetal hemoglobin (HbF) is more sensitive to oxidizing chemicals such as the nitrite ion. As the
concentration of HbF decreases, so does the susceptibility to nitrite. By the end of the first year
all HbF is substituted for adult hemoglobin, the baby is hematologically an adult.
4) Infants are deficient of certain enzymes that keep the iron in the reduced state during the first
several months of life.
Now you know that nitrite cause the formation of methemoglobin. Then our question is actually: "Why
does methemoglobin cause cyanosis as if not enough oxygen was delivered to cells?"
Structurally methemoglobin is equivalent to oxyhemoglobin. It has instead oxygen water bound.
Hint: Shown to the right is the situation in which half of
Fe(II) got oxidized to Fe(III). The pressure of oxygen in
arterial blood is about 100 mm Hg and in the veins 35 mm
Hg.
1.0
Hb
0.8 -
Met-Hb
Y 06
04
F, 2/18- The Spanish Voyages of Exploration, 1492-1522
MacBook Air
80
F3
םםב
4)
F5
F6
F7
F8
F9
F10
&
4.
5
7
8
9
T.
Y
U
P
< 6
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