Normal Translocation chromosomes chromosomes Philadelphia chromosome 22 Direction bcry of bạr abl abl transcription Abnormal This translocation crossover results in the abnormal expression of a BCR/ABL fusion protein in white blood cells, thereby causing chronic myelogenous leukemia. FIGURE 25.13 The reciprocal translocation commonly found in people with chronic myelogenous leukemia. Genes-Traits In healthy individuals, the abl gene is located on chromosome 9, and the bcr gene is on chromosome 22. In certain forms of myelogenous leukemia, a reciprocal translocation causes the abl gene to fuse with the bcr gene. This combined gene, under the control of the bcr promoter, encodes an abnormal fusion protein that overexpresses the tyrosine kinase function of the ABL protein in white blood cells and leads to leukemia.

Q: What is the Delta variant and how is it impeding on getting things back to "normal"?

A: The disease is a condition that is caused by a deviation from the normal. Majority of the disease is…

Q: What are alternative forms of a single gene?

A: The genes are the sequence of nucleotides that are present on the chromosomes and encode for a…

Q: In a few sentences, describe how p53 guards the genome. Include at least two specific ways that p53…

A: The TP53 ( Tumor protein 53) also known as P53. This gene codes for cell cycle regulatory proteins…

Q: What does the BCR gene do?

A: A short-portion of the DNA is termed as a gene. The genes are the essential functions as well as…

Q: What is a heterochronic mutation? How does it affect the phenotypic outcome of an organism? What…

A: Mutation means sudden changes occur in DNA sequences. The mutation occurs randomly. It also occurs…

Q: “In an organism that reproduces asexually, there is no difference between a somatic cell mutation…

A: Somatic mutations These refers to the mutations in a single body cell, which cannot be inherited.…

Q: Explain in detail the meaning of gene fusion. How is this process related to prostate cancer…

A: A gene is referred to as the smallest structural and functional unit of heredity. They are made up…

Q: The phenotype of a heterozygous mouse (Aa) is agouti.  The agouti banding pattern is due to altered…

A: * Homozygous dominant and Heterozygous will produce agouti that is AA or Aa respectively  and the…

Q: 11. Using the hypothetical pathway below, determine what proportion of offspring will be Orange if…

A: In this pathway, the presence of orange colour means the absence of C and the presence of A+ B in…

Q: What protein does the P53 code for and why is it important?

A: Answer :- The TP53 quality gives guidelines to making a protein called growth protein p53 (or p53).…

Q: What does it mean for a mutation to be allelic?

A: Mutation is the alteration in the nucleotide sequence of the genome of an organism. It takes place…

Q: Why is mutation breeding necessary for breeding for disease resistance?

A: Breeding is defined as sexual reproduction occurring between two organisms of the opposite sex of…

Q: Which of the following is most influenced by the SRY gene?

A: Introduction  Chromosomes are classified into two types: Autosomes and Allosomes/Sex chromosomes.…

Q: How can you tell if an individual is heterozygous for the D1S80 marker?

A: The term heterozygous variant belongs to a subdivision of biology, genetics. Genetics is the study…

Q: What does the ABL gene do?

A: The deoxyribonucleic acid (DNA) is the hereditary material that transmits the genetic information…

Q: Is it possible for a severe mutation-causing hereditary condition to pass down from generation to…

A: A mutation can be defined as change in the sequence of genetic letters, called bases, within a…

Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…

A:

Q: can two observably different cells have the same geno type, explain?

A: In biology, the genotype is the set of genes in our DNA which is responsible for a particular trait.…

Q: Many people with mutated alleles that are associated with diseases, including some cancers, do not…

A: A rapid change in the sequence of DNA (deoxyribonucleic acid) due to physical or chemical factors is…

Inheritance and Mendelian Genetics

Inheritance means the passing of traits to offspring from parents. These traits could be passed either through asexual reproduction or sexual reproduction. The offspring receives the genetic material from the parents. Mendelian inheritance is a certain biological inheritance that follows the rules and principles laid down by Gregor Mendel in 1865. The initial hypothesis was considered wrong, but other inheritance theories modified the concept of inheritance and thus genetics.