NO2 1) H 2CrO4 2) CH3OH, H+ 3) CH3MgCl 4) H+

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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provide the product given the starting material and the reagants.

The image depicts a chemical reaction sequence beginning with a benzene ring substituted with a nitro group (NO₂) and another substituent labeled as "Nu₂." The following reagents and conditions are indicated for each step in the reaction sequence:

1. **H₂CrO₄ (Chromic Acid)**
2. **CH₃OH (Methanol), H⁺ (Acidic Conditions)**
3. **CH₃MgCl (Methylmagnesium Chloride, a Grignard Reagent)**
4. **H⁺ (Acidic Work-up)**

Reagent 1, H₂CrO₄, is typically used for the oxidation of primary alcohols to carboxylic acids or secondary alcohols to ketones.

Reagent 2, CH₃OH in the presence of an acid, suggests a potential esterification or transesterification process.

Reagent 3, CH₃MgCl, is a Grignard reagent used for forming carbon-carbon bonds, which can result in the addition of a methyl group to a carbonyl compound (ketone or aldehyde).

Reagent 4 is an acidic work-up step, potentially to protonate an alkoxide intermediate formed during the Grignard reaction.

The diagram does not show the final product of the reaction sequence, leaving the outcome open-ended for educational analysis and prediction based on the provided reagents and conditions.
Transcribed Image Text:The image depicts a chemical reaction sequence beginning with a benzene ring substituted with a nitro group (NO₂) and another substituent labeled as "Nu₂." The following reagents and conditions are indicated for each step in the reaction sequence: 1. **H₂CrO₄ (Chromic Acid)** 2. **CH₃OH (Methanol), H⁺ (Acidic Conditions)** 3. **CH₃MgCl (Methylmagnesium Chloride, a Grignard Reagent)** 4. **H⁺ (Acidic Work-up)** Reagent 1, H₂CrO₄, is typically used for the oxidation of primary alcohols to carboxylic acids or secondary alcohols to ketones. Reagent 2, CH₃OH in the presence of an acid, suggests a potential esterification or transesterification process. Reagent 3, CH₃MgCl, is a Grignard reagent used for forming carbon-carbon bonds, which can result in the addition of a methyl group to a carbonyl compound (ketone or aldehyde). Reagent 4 is an acidic work-up step, potentially to protonate an alkoxide intermediate formed during the Grignard reaction. The diagram does not show the final product of the reaction sequence, leaving the outcome open-ended for educational analysis and prediction based on the provided reagents and conditions.
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