НО. НО. (above product not formed) The Grignard reagent will deprotonate the carboxylic acid because the carboxylic acid is a stronger base than the conjugate acid of the Grignard reagent. The Grignard reagent will add to the carboxylic acid instead of the ketone because the carboxylic acid is more electrophilic. The Grignard reagent will add to both the ketone and carbonyl, and the carboxylic acid will be reduced to an alcohol with two ethyl groups attached. The wrong product is written. A methyl group should be added to the ketone carbonyl instead of an ethyl group.

НО. НО. (above product not formed) The Grignard reagent will deprotonate the carboxylic acid because the carboxylic acid is a stronger base than the conjugate acid of the Grignard reagent. The Grignard reagent will add to the carboxylic acid instead of the ketone because the carboxylic acid is more electrophilic. The Grignard reagent will add to both the ketone and carbonyl, and the carboxylic acid will be reduced to an alcohol with two ethyl groups attached. The wrong product is written. A methyl group should be added to the ketone carbonyl instead of an ethyl group.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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The reaction of a Grignard reagent with a carboxylic acid does not give a secondary alcohol because Grignard reagents only react with aldehydes, ketones, esters, and epoxides. O The carboxylic acid is too sterically hindered to react. The carboxylic acid is not electrophilic enough to react. The Grignard reagent is a base, so an acid-base reaction occurs.
MC1. Grignard reagent and organolithium reagents can be prepared in presence of acidic functional groups. MC2. Gilman reagents react with formaldehyde and gives alcohol. MC3. An SN2 attack on the chiral center would result in inversion of stereochemistry. MC4. Acetal cannot be formed in base as the -OH group is a bad leaving group. MC5. Carbon dioxide can readily react with Gilman reagent to form carboxylic acid. MC6. Alkynes anion are powerful nucleophiles that react with epoxides, aldehyde and ketones. MC7. Simple phosphonium yilde forms the Z product which is the thermodynamic product. MC8. When the reaction is under kinetic control the ratio of the products formed is determined by the relative energies of the transition states. MC9. A significant concentration of strong acids and strong bases cannot co-exist in the same reaction. MC10. The driving force for the Wittig reaction is the formation of a strong carbon-carbon double bond. MC11. A baby-shark trap can be used to remove…
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