NH3 ÇI CHPt-Cl Cl-Pt-NH3 NH3 NH3

Chemistry: Principles and Reactions
8th Edition
ISBN:9781305079373
Author:William L. Masterton, Cecile N. Hurley
Publisher:William L. Masterton, Cecile N. Hurley
Chapter7: Covalent Bonding
Section: Chapter Questions
Problem 38QAP
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There are two compounds of the formula Pt(NH3)2Cl2:

The compound on the right is called cisplatin, and the compound
on the left is called transplatin. (a) Which compound
has a nonzero dipole moment? (b) One of these compounds
is an anticancer drug, and one is inactive. The anticancer
drug works by its chloride ions undergoing a substitution
reaction with nitrogen atoms in DNA that are close together,
forming a N—Pt—N angle of about 90°. Which compound
would you predict to be the anticancer drug?

NH3
ÇI
CHPt-Cl
Cl-Pt-NH3
NH3
NH3
Transcribed Image Text:NH3 ÇI CHPt-Cl Cl-Pt-NH3 NH3 NH3
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