NH2 HO Atenolol Tenormin® Below is a two-step reaction sequence. What are the steps in the synthesis? `NH2 -NH2 `NH2 base OH Он O The phenolate reacts with the epoxide preferentially over the alkyl halide at the less sterically hindered position. Then, the sterically hindered amine attacks the alkyl chloride. The phenolate reacts with the epoxide preferentially over the alkyl halide at the more sterically hindered position. Then, the sterically hindered amine attacks the alkyl chloride.

NH2 HO Atenolol Tenormin® Below is a two-step reaction sequence. What are the steps in the synthesis? `NH2 -NH2 `NH2 base OH Он O The phenolate reacts with the epoxide preferentially over the alkyl halide at the less sterically hindered position. Then, the sterically hindered amine attacks the alkyl chloride. The phenolate reacts with the epoxide preferentially over the alkyl halide at the more sterically hindered position. Then, the sterically hindered amine attacks the alkyl chloride.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

10. Which of the following compounds does not undergo hydrolysis with either acid or basic catalysis: 00 H3Cca CH3CH2ČNH2 CHICOCHCH3 CH3COCH2CH2CH3 B. CHICCH2CH3 F. None of the molecules shown undergoes hydrolysis.
The compound having the HIGHEST percentage of cyclic hemiacetal at equilibrium is Compound The compound having the LOWEST percentage of cyclic hemiacetal at equilibrium is Compound OH OH OH H H F F Me D
The starting material that completes the following reaction is: 1) NH3 2) H₂/Ni ? Draw Your Solution NH2
What are the major productís) of the following reaction? (You may choose more than one answer.) 1. NaOH 2. H* п 1-propanol 2-propanol butanol propanoic acid 2-propanone butanoic acid n 1-methylethyl propanoate none of the above
Which of the following reactions would produce an enamine as the major product? Assume that there are means to remove water from the reaction. A a b C C D d E e HN product NaCN, acetone H. A pH 4-5 D product H CH;NH2 product H2N– NH2 рH 4-5 → product H pH 4-5 HN. + product pH 4-5 B.
1. Rank the following substances in order of increasing reactivity towards nucleophilic acyl substitution (the least reactive is 1 and the most reactive is 5). 요 OPh HO
Write what are the products A, B and C formed in the following reaction steps.
4. Show how you might prepare lactic acid from acetaldehyde through a cyanohydrin intermediate. Н ОН CO H
What is the best choice of reagent to achieve the following reaction? ? H2/Pd NaOH, H₂O H2SO4 K2Cr2O7, H2SO4 CH3 + CH3CH2OH