н H30* -N: EN х enamine imine

Q: Why is it not advisable to use aqueous hydrochloric acid in a Grignard reaction of a ketone? A) The…

A: Alkyl magnesium halide is known as a Grignard reagent. The general formula of the Grignard reagent…

Q: Identify compounds A–C in the attached reaction scheme.

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Q: Tautomerization in base resembles tautomerization in acid, but deprotonation precedes protonation in…

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Q: Identify A in the following reaction sequence, and draw a mechanism for the conversion of A to B. B…

A: In Sharpless epoxidation, the epoxidation of the double bond will take place. Note:- Direction…

Q: Identify the lettered compounds in each reaction sequence.Draw the product formed when…

A: Grignard reagent acts as a nucleophile whereas the C of CO is an electrophilic centre.

Q: When (R)-6-bromo-2,6-dimethylnonane is dissolved in CH3OH,nucleophilic substitution yields an…

A: The structure of given compounds are shown below:

Q: Draw a stepwise mechanism for the following reaction, a key step in the synthesis of the…

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.