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6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon * Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite

6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon * Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Help me answer 6a based on my note it says no reaction for 4 carbons? how do i count carbons on chain? thank you 

6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP
Transcribed Image Text:6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP
N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon * Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite
Transcribed Image Text:N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon * Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite
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