Muscle contraction is the result of critical stepscharacterized by conformational changes to proteinstructures in the supramolecule. Which of the followingconformational changes requires energy, i.e. ATPhydrolysis?A. Binding of calcium to tropomyosin changing itsconformation and exposing a binding site in troponinB. Binding of myosin to troponin resulting in the powerstroke and cross-bridge cycle of muscle contraction.C. Disruption in the binding of the myosin head to troponinpreceding its release and relaxation back to its activatedform.D. Binding of ATP to the myosin head bound to troponin.

Muscle contraction is the result of critical steps characterized by conformational changes to…

Answered: Muscle contraction is the result of…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Considering the Length-Tension Relationship of skeletal muscle fibers, over stretching a muscle fiber or not stretching a muscle fiber enough, results ina decrease in force developed (during contraction) because: 27. A. An "over-stretched" muscle fiber or an “under-stretched" muscle fiber will not allow Calcium, from the sarcoplasmic reticulum, to adequately diffuse into the cytoplasm. B. An "over-stretched" muscle fiber or an "under-stretched" muscle fiber will not allow an optimum amount of contact and overlap for the contractile proteins. C. An "over-stretched" muscle fiber or an“under-stretched" muscle fiber will not allow the Action Potential to reach the troponin-activation channels. D. An "over-stretched" muscle fiber or an "under-stretched" muscle fiber will not allow the Sodium current to depolarize the membrane. Teurons to
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Researchers are working to understand a rare disease that affects the ability of the muscles to contract. They have identified that the disease is caused by abnormal gene expression leading to a relatively large intracellular space between the T-tubules and the terminal cisternae in the triad, which causes an interruption in the connection between the dihydropyridine (DHP) receptor and the ryanodine calcium channel. Based on this description of the morphology underlying the disease, which of the following problems would you expect in excitation-contraction coupling? An action potential would not be able to be transmitted down the T-tubule. Re-uptake of calcium would be blocked, leading to an increase in intracellular calcium. O The actin binding sites may continue to be blocked by tropomyosin even following an action potential along the sarcolemma. O All of the above. Only B and C.
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Which of the following happens last in the sliding filament theory? A. Tropomyosin Shifts B. Calcium binds to troponin C. Myosin binds to actin D. Myosin heads undergo the powerstroke

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