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molecule in each ionization state. H|| H,N*-C-C- OH H|| H,N-C-C-0- H I H,N-C-C-0- H,N-C-C-C CH, CH, CH2 CH, HN HN -NH -NH -NH -NH Answer Bank -1 +1 +2 PK, = 1.8 -2 PK, = 9,17 PK, = 7.59 %3D pK, = 6.0 %3D .....

molecule in each ionization state. H|| H,N*-C-C- OH H|| H,N-C-C-0- H I H,N-C-C-0- H,N-C-C-C CH, CH, CH2 CH, HN HN -NH -NH -NH -NH Answer Bank -1 +1 +2 PK, = 1.8 -2 PK, = 9,17 PK, = 7.59 %3D pK, = 6.0 %3D .....

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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on 2 of 3 Hint Resume Question Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional group is determined by the relationship between its pK, and the pH of the solution. This relationship is described by the Henderson-Hasselbalch equation. Histidine has three ionizable functional groups. Complete the equilibrium equations by assigning the proper pK, for each ionization and the net charge on the histidine molecule in each ionization state. H H H,N*-C-C-OH H,N*-C-C-o- H,N*-C-C-o- H,N-C-C-o- CH, CH, CH, CH, HN HN N' -NH -NH -NH -NH ......... Answer Bank -2 pK, = 9,17 -1 +1 pKa = 6.0 pK, = 7.59 pK, = 1.8 of Fi..docx DD DII F11 F10 FB F7 888 F6 80 F5 F4 F3 & %24 6 7 4. 5 U R 1 1 o=U
Transcribed Image Text:on 2 of 3 Hint Resume Question Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional group is determined by the relationship between its pK, and the pH of the solution. This relationship is described by the Henderson-Hasselbalch equation. Histidine has three ionizable functional groups. Complete the equilibrium equations by assigning the proper pK, for each ionization and the net charge on the histidine molecule in each ionization state. H H H,N*-C-C-OH H,N*-C-C-o- H,N*-C-C-o- H,N-C-C-o- CH, CH, CH, CH, HN HN N' -NH -NH -NH -NH ......... Answer Bank -2 pK, = 9,17 -1 +1 pKa = 6.0 pK, = 7.59 pK, = 1.8 of Fi..docx DD DII F11 F10 FB F7 888 F6 80 F5 F4 F3 & %24 6 7 4. 5 U R 1 1 o=U
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