Microbiology A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-µg netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on each of the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11. *6.18 Provide a point and interval estimate (95% CI) for the mean zone diameter across laboratories for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.19 Answer Problem 6.18 assuming each laboratory uses a common medium to perform the susceptibility tests. *6.20 Provide a point and interval estimate (95% CI) for the interlaboratory standard deviation of mean zone diameters for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.21 Answer Problem 6.20 assuming each laboratory uses a common medium to perform the susceptibility tests. 6.22 Are there any advantages to using a common medium versus using different media for performing the susceptibil- ity tests with regard to standardization of results across laboratories?

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patients discharged from Pennsylvania hospitals.
Microbiology
A nine-laboratory cooperative study was performed to
evaluate quality control for susceptibility tests with 30-ug
netilmicin disks [6]. Each laboratory tested three standard
control strains on a different lot of Mueller-Hinton agar, with
150 tests performed per laboratory. For protocol control,
each laboratory also performed 15 additional tests on each
of the control strains using the same lot of Mueller-Hinton
agar across laboratories. The mean zone diameters for each
of the nine laboratories are given in Table 6.11.
*6.18 Provide a point and interval estimate (95% CI) for
the mean zone diameter across laboratories for each type
of control strain, assuming each laboratory uses different
media to perform the susceptibility tests.
*6.19 Answer Problem 6.18 assuming each laboratory uses
a common medium to perform the susceptibility tests.
*6.20 Provide a point and interval estimate (95% CI) for the
interlaboratory standard deviation of mean zone diameters
for each type of control strain, assuming each laboratory
uses different media to perform the susceptibility tests.
*6.21 Answer Problem 6.20 assuming each laboratory uses
a common medium to perform the susceptibility tests.
6.22 Are there any advantages to using a common medium
versus using different media for performing the susceptibil-
ity tests with regard to standardization of results across
laboratories?
Transcribed Image Text:patients discharged from Pennsylvania hospitals. Microbiology A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-ug netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on each of the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11. *6.18 Provide a point and interval estimate (95% CI) for the mean zone diameter across laboratories for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.19 Answer Problem 6.18 assuming each laboratory uses a common medium to perform the susceptibility tests. *6.20 Provide a point and interval estimate (95% CI) for the interlaboratory standard deviation of mean zone diameters for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.21 Answer Problem 6.20 assuming each laboratory uses a common medium to perform the susceptibility tests. 6.22 Are there any advantages to using a common medium versus using different media for performing the susceptibil- ity tests with regard to standardization of results across laboratories?
patients discharged from Pennsylvania hospitals.
Microbiology
A nine-laboratory cooperative study was performed to
evaluate quality control for susceptibility tests with 30-ug
netilmicin disks [6]. Each laboratory tested three standard
control strains on a different lot of Mueller-Hinton agar, with
150 tests performed per laboratory. For protocol control,
each laboratory also performed 15 additional tests on each
of the control strains using the same lot of Mueller-Hinton
agar across laboratories. The mean zone diameters for each
of the nine laboratories are given in Table 6.11.
*6.18 Provide a point and interval estimate (95% CI) for
the mean zone diameter across laboratories for each type
of control strain, assuming each laboratory uses different
media to perform the susceptibility tests.
*6.19 Answer Problem 6.18 assuming each laboratory uses
a common medium to perform the susceptibility tests.
*6.20 Provide a point and interval estimate (95% CI) for the
interlaboratory standard deviation of mean zone diameters
for each type of control strain, assuming each laboratory
uses different media to perform the susceptibility tests.
*6.21 Answer Problem 6.20 assuming each laboratory uses
a common medium to perform the susceptibility tests.
6.22 Are there any advantages to using a common medium
versus using different media for performing the susceptibil-
ity tests with regard to standardization of results across
laboratories?
Transcribed Image Text:patients discharged from Pennsylvania hospitals. Microbiology A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-ug netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on each of the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11. *6.18 Provide a point and interval estimate (95% CI) for the mean zone diameter across laboratories for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.19 Answer Problem 6.18 assuming each laboratory uses a common medium to perform the susceptibility tests. *6.20 Provide a point and interval estimate (95% CI) for the interlaboratory standard deviation of mean zone diameters for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.21 Answer Problem 6.20 assuming each laboratory uses a common medium to perform the susceptibility tests. 6.22 Are there any advantages to using a common medium versus using different media for performing the susceptibil- ity tests with regard to standardization of results across laboratories?
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