Match the consequence of a loss-of-function mutation in DNA polymerase I to the corresponding lost activity.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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DNA polymerase I has 5'-3' polymerase activity, 5'-3' exonuclease activity, and 3'-5' exonuclease activity necessary for
DNA replication. Mutations in the gene that encodes DNA polymerase I may cause the enzyme to lose these activities.
Match the consequence of a loss-of-function mutation in DNA polymerase I to the corresponding lost activity.
Lost 5'-3' polymerase activity
no RNA primer removal during DNA replication
no double helix denaturation
Lost 5'-3' exonuclease activity
Answer Bank
decreased polymerase fidelity
Lost 3'-5' exonuclease activity
no DNA synthesis to fill gaps caused by removing RNA primers
unstable strand separation within the replication bubble
Transcribed Image Text:DNA polymerase I has 5'-3' polymerase activity, 5'-3' exonuclease activity, and 3'-5' exonuclease activity necessary for DNA replication. Mutations in the gene that encodes DNA polymerase I may cause the enzyme to lose these activities. Match the consequence of a loss-of-function mutation in DNA polymerase I to the corresponding lost activity. Lost 5'-3' polymerase activity no RNA primer removal during DNA replication no double helix denaturation Lost 5'-3' exonuclease activity Answer Bank decreased polymerase fidelity Lost 3'-5' exonuclease activity no DNA synthesis to fill gaps caused by removing RNA primers unstable strand separation within the replication bubble
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