Answered: Lysine 4 of histone H3 (H3K4) is…

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter19: Genomes And Proteomes

Section: Chapter Questions

Problem 1ITD: Below is a sequence of 540 bases from a genome. What information would you use to find the...

See similar textbooks

Related questions

Question

Lysine 4 of histone H3 (H3K4) is methylated in the
nucleosomes of many transcriptionally active genes.
Suppose you want to determine all the places in the
human genome where nucleosomes contain methylated H3K4.
a. Starting with an antibody that specifically binds
only to the tails of histone H3s that have K4 methylation, what kind of experiment would you perform? Outline the major steps of this experiment.
b. Do you think that you would get the same results if
your starting material was skin cells in one experiment and blood precursor cells in a second experiment? Explain.
c. Describe a follow-up experiment that could determine if your data from part (a) are consistent with
the idea that H3K4 methylation marks appear only
at transcriptionally active genes

Expert Solution

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions