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- Insulin Lispro subcutaneously for a patient weight 80 kg for 1 month of treatment. Daily dose of insulin is 1 Unit/kg and 60% in short acting, given 4 times per day; ampoules in form of personal injectors (300 Units/3ml). (I would like to figure out the number of personal injector needed for 1 month.) My answer: Daily dose (DD) for a 80 kg patient = 80 x 1 Unit = 80 U 60% is short acting, so DD = 60% of 80 U = (0.6 × 80) U = 48 U Given 4 times per day, so for a single dose = 48 U/4 = 12 U For 1 month (30 days), 30 x 48U = 1440 U Rp. Insulin lispro in ampoules personal injectors 300 Units/3 ml No. ??? (my teacher write is 10 but I don't understand why) Sig. Inject subcutaneously 12 Unit (0.12 ml) before each meal, 4 times a day for 1 month.A newborn girl appeared normal at birth, but within 24 hours she developed lethargy,hypothermia, and apnea. The attending physician suspects a metabolic disorder andorders a panel of labs.A full blood work up was ordered for this female and the data is presented below.The initial blood ammonia level was elevated at 314 ug/dl (normal range = 17–80) andrapidly rose to 600 ug/dl.Discuss the normal mechanisms of ammonia transfer in the body that should beoccurring, including glutamate dehydrogenase, glutaminase and glutamine synthetase.Be sure to discuss the role of transamination. How is nitrogen transport connected to gluconeogenesis in the fasted state? Further analysis shows urine orotic acid levels were markedly elevated at 473 umol/Lcreatinine (nl = 0– 3). The plasma citrulline level was normal at 10 uM/L (nl = 12–55).In thisindividual, where orotic acid levels are elevated, what urea cycle enzyme is mostlikely deficient and what urea cycle enzyme isleast likely to be impaired? (Be…Elevated blood plasma levels of alkaline phosphatase (hyperphosphatasaemia) are an indication of a number of pathologies. Briefly comment on the use of alkaline phosphatase assays as a diagnostic aid for a single common medical condition. (word limit 120 words including citations and references.
- Situation B: Mr. Mahmood, a 45-year-old man was trapped in the lift with no water and food. It was nearly more than 2 days (> 48 hours) before he was discovered and rescued. i. Identify the physiological state. ii. Explain the biochemical responses and hormone(s) implicated.What would happen to the patient if the serum cholinesterase activity were only 10 units of activity per liter rather than the normal activity of about 80 units?A 10-week-old child suffered from a salt-wasting crisis. His adrenal glands were enlarged and other organs were normal size. The child is phenotypically female, karotyping showed that the child is 46XY. The biochemical profile shows as: - sodium of 109 (reference range: 134-147) - potassium of 6.1 (reference range: 3.5-5.0) - pregnenlone of 0.002 (reference range: 0.3-1.5) - renin activity of 38 (reference range: 0.5-3.5) - 17-OH pregnenolone of 0.01 (reference range: 6.8-93.5) - ACTH of 1960 (reference range: 0.5-3.5) The cholesterol esters in the adrenal glands accumulated and the concentration of ∆4-androstenedione was not detectable. Also, the enzymes in the steroid biosynthesis did not have detrimental mutations. The child was given treatment with glucocorticoid and mineralocorticoid. Question: a) Which protein is deficient in this case and explain the rationale.
- 20:37 E Document (69) Question 3 You are referred as 49yrs old man from the Asante Akyem South District specifically Juaso for an-ongoing care after having suffered an Acute Myocardial Infarction. The results from the cardiologist states the patient is apparently not hypercholesterolaemic but is somewhat obese and his father died of a "heart attack" at 59yrs of age. On clinical examination you confirmed the obesity (BMI- 31), the patient's Bp is 165/105mmHg, he admits to smoking 20-30 cigarette a day until his AMI, but no overt evidence of hyperlipidaemia is detected. Other than his father, there is no clear history of premature Coronary Arthery Disease (CAD) in his family. His Total fasting Cholesterol is 5.2mmol/L, HDL- Cholesterol- 0.8 mmol/L, triglycerides- 2.7mmol/L Reference Total Cholesterol (3.10- 6.50mmol/L) HDL- Cholesterol (1.03- 1.55mmol/L) Triglycerides (0.3-1.70 mmol/L) LDL- Cholesterol (2.60- 4.90mmol/L) (A) Discuss the lipid profile in terms of its risk potential and…a 50-year-old woman with a body mass index in the obese range had a weakness in their muscles. she had a history of increased blood pressure but controlled it with medication. the GP has diagnosed her with extreme hypertension and therefore has given her an increased dosage of blood pressure medication but did not have an effect on her hypertension. the biochemical profile shows: - urea of 8.9 (reference range: 2.5-7.0) - sodium of 162 (reference range: 134-147) - potassium of 2.2 (reference range: 3.5-5.0) -aldosterone of 863 (reference range: 90-700) - renin activity of 4.3 (reference range: 0.5-3.5) - aldosterone/RA ratio of 201 (reference range: <680) -cortisol of 511 (reference range: 138-690) -pH of 7.51 ( reference range : 7.35-7.45) Questions: a)what is the medical condition the patient has and what are the causes? fully explain the rationale which is based on the patients history and the test results indicated above. b)which non invasive test will be taken into…Describe the two phases of the the HMP shunt. Enumerate the reactions in each phase and the corresponding enzyme of each reation. Explain how the HMP shunt is regulated?
- Are statins the best course of treatment for hypercholesterolemia in adults? Why or why not?Propionic acidemia has a relatively high prevalence in South Africa, among both black and white families. This fatal disease is often diagnosed by the elevated presence of propionyl carnitine, propionylglycine and methyl citrate in blood and urine. Discuss the metabolism involved and origin of these markers.Name: Hendric Nduwuba DNP and Cellular Respiration Summary https://www.youtube.com/watch?v=eLtRan2qFx0 Your assignment today is to summarize in two paragraphs (8 sentences total) the effects of dinitrophenol (DNP) on the human body. Make sure you explain what DNP is, the stages of cellular respiration, and how DNP alters the metabolism of the person using it (side effects). The following vocabulary terms need to be used: cellular respiration, adenosine triphosphate, and dinitrophenol (DNP). Your objective is to describe the role of ATP in cellular respiration in order to explain how DNP affects the rate of metabolism. The first paragraph is an introduction to the summary and the second paragraph is an explanation of the main idea. You will be graded on this criteria: main idea, explanation of cellular respiration, explanation of DNP, and paragraph structure.