11 O Macmillan LearningLipids in a bilayer can diffuse laterally at a relatively fast rate, but "flip-flop" from one leaflet to the other very slowly withoutcatalysis. Three protein families, flippases (or flipases), floppases, and scramblases, catalyze the movement of lipids acrossthe bilayer.Classify each phrase as describing flippases, floppases, or scramblases.Flippasesnot ATP-dependentFloppasesAnswer Banktranslocate phosphatidylserine, preventing apoptosis and engulfment by macrophagesWWWnmove phospholipids across the lipid bilayer down the concentration gradienttranslocate lipids from outer (extracellular) leaflet to inner (cytosolic) leafletmove phospholipids from inner (cytoplasmic) leaflet to outer (extracellular) leafletAttemptABC transporterScramblasesactivation may result in increased membrane lipid symmetry

Flippases, floppases, and scramblases are phospholipid translocators present in the membrane bilayer.All these transporters catalyzed the movement of phospholipids across the membrane in an ATP-dependent or independent manner.FlippasesFloppasesScramblesABC transporters.Not ATP-dependent.Translocate lipids from the outer (extracellular) leaflet to the inner (cytoplasmic) leaflet. Move phospholipids from the inner (cytoplasmic) leaflet to the outer (extracellular) leaflet. Move phospholipids across the lipid bilayer down the concentration gradient. activation may result in increased membrane lipid symmetry. Translocate phosphatidylserine, preventing apoptosis and engulfment by macrophages.Activation may result in increased membrane lipid symmetry.