Lidocaine is a medication used to numb tissue in a specific area (local anesthetic). When used as an injectable, lidocaine typically begins working within four minutes and lasts for half an hour to three hours. Common side effects with intravenous N. N. use include sleepiness, muscle twitching, and confusion, changes in vision, numbness, tingling, and vomiting. It can cause low blood pressure and an irregular heart rate. 5. There are several new, green methods to prepare amides (see below). Choose the best method and explain why you onsider that method the best. Also predict the mechanism to prepare lidocaine with that method. The above is a sulfa drug, the first class of antibiotics ever discovered. Your job is to synthesize the amine into an amide. Would you do this under acidic or basic conditions?

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Lidocaine is a medication used to numb tissue in a specific
area (local anesthetic). When used as an injectable, lidocaine
typically begins working within four minutes and lasts for half
an hour to three hours. Common side effects with intravenous
use include sleepiness, muscle twitching, and confusion,
changes in vision, numbness, tingling, and vomiting. It can
cause low blood pressure and an irregular heart rate.
5. There are several new, green methods to prepare amides (see below). Choose the best
method and explain why you fonsider that method the best. Also predict the mechanism
to prepare lidocaine with that method.
The above is a sulfa drug, the first class of antibiotics ever discovered. Your job is to
synthesize the amine into an amide. Would you do this under acidic or basic conditions?
Transcribed Image Text:Lidocaine is a medication used to numb tissue in a specific area (local anesthetic). When used as an injectable, lidocaine typically begins working within four minutes and lasts for half an hour to three hours. Common side effects with intravenous use include sleepiness, muscle twitching, and confusion, changes in vision, numbness, tingling, and vomiting. It can cause low blood pressure and an irregular heart rate. 5. There are several new, green methods to prepare amides (see below). Choose the best method and explain why you fonsider that method the best. Also predict the mechanism to prepare lidocaine with that method. The above is a sulfa drug, the first class of antibiotics ever discovered. Your job is to synthesize the amine into an amide. Would you do this under acidic or basic conditions?
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