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"Leptin is a circulating hormone that is produced by fat cells and plays a role in body metabolism and obesity. It normally binds to receptors in the brain and inhibits appetite. Studies have demonstrated that when obese mice that are leptin deficient are injected with leptin they quickly lose their excess weight. Interestingly, however, many overweight people have high levels of leptin in their bloodstream. Why do you think that the high levels of leptin in obese individuals are insufficient to curb their appetite?" O Paracrine signaling may be disrupted in obese people with high levels of leptin. O Obese people who have high levels of leptin may have a leptin receptor with decreased sensitivity. O The form of leptin released by obese people may lack protein kinase activity. O "In obese people with high levels of leptin, the leptin is a non-functional second messenger."

"Leptin is a circulating hormone that is produced by fat cells and plays a role in body metabolism and obesity. It normally binds to receptors in the brain and inhibits appetite. Studies have demonstrated that when obese mice that are leptin deficient are injected with leptin they quickly lose their excess weight. Interestingly, however, many overweight people have high levels of leptin in their bloodstream. Why do you think that the high levels of leptin in obese individuals are insufficient to curb their appetite?" O Paracrine signaling may be disrupted in obese people with high levels of leptin. O Obese people who have high levels of leptin may have a leptin receptor with decreased sensitivity. O The form of leptin released by obese people may lack protein kinase activity. O "In obese people with high levels of leptin, the leptin is a non-functional second messenger."

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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"Leptin is a circulating hormone that is produced by fat cells and plays a role in body metabolism and obesity. It normally binds to receptors in the brain and inhibits appetite. Studies have demonstrated that when obese mice that are leptin deficient are injected with leptin they quickly lose their excess weight. Interestingly, however, many overweight people have high levels of leptin in their bloodstream. Why do you think that the high levels of leptin in obese individuals are insufficient to curb their appetite?" O Paracrine signaling may be disrupted in obese people with high levels of leptin. O Obese people who have high levels of leptin may have a leptin receptor with decreased sensitivity. O The form of leptin released by obese people may lack protein kinase activity. O "In obese people with high levels of leptin, the leptin is a non-functional second messenger."
Transcribed Image Text:"Leptin is a circulating hormone that is produced by fat cells and plays a role in body metabolism and obesity. It normally binds to receptors in the brain and inhibits appetite. Studies have demonstrated that when obese mice that are leptin deficient are injected with leptin they quickly lose their excess weight. Interestingly, however, many overweight people have high levels of leptin in their bloodstream. Why do you think that the high levels of leptin in obese individuals are insufficient to curb their appetite?" O Paracrine signaling may be disrupted in obese people with high levels of leptin. O Obese people who have high levels of leptin may have a leptin receptor with decreased sensitivity. O The form of leptin released by obese people may lack protein kinase activity. O "In obese people with high levels of leptin, the leptin is a non-functional second messenger."
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