LDA (CH),SiCI (CH;);CCI ZnCl, What is the major product? b. с. d. e. not a.-d.

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Chapter1: Chemical Foundations
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**Question 4: What is the major product?**

This question involves a chemical reaction sequence and asks for the identification of the major product formed. The reaction begins with a cyclic diketone substrate (a six-membered ring with two ketone groups on adjacent carbon atoms) and undergoes a transformation involving the following steps:

1. **LDA (Lithium Diisopropylamide)** - This is a strong base used to deprotonate the diketone, likely forming an enolate ion as an intermediate.
2. **(CH₃)₃SiCl (Trimethylsilyl chloride)** - This reagent is often utilized to protect or modify functional groups. It reacts with the enolate intermediate.
3. **(CH₃)₃CCl (Tert-butyl chloride)** in the presence of **ZnCl₂ (Zinc chloride)** - This combination suggests a Friedel-Crafts reaction, likely introducing a tert-butyl group onto the ring.

**Options for the Major Product:**

a. A six-membered ring with a tert-butyl group and two ketone groups.

b. A six-membered ring with two ketone groups and no additional substituents.

c. A six-membered ring with an isolated double bond, one ketone group, and a tert-butyl group.

d. A six-membered ring with two ketone groups and a tert-butyl group attached at a different position from option a.

e. None of the above (not a.-d.).

The illustration presents potential structural outcomes from the reaction steps. Each option depicts variations in substituent positions and connectivity on the cyclic diketone structure after the reaction sequence, assessing possible regioselectivity and stereochemistry of the reaction.
Transcribed Image Text:**Question 4: What is the major product?** This question involves a chemical reaction sequence and asks for the identification of the major product formed. The reaction begins with a cyclic diketone substrate (a six-membered ring with two ketone groups on adjacent carbon atoms) and undergoes a transformation involving the following steps: 1. **LDA (Lithium Diisopropylamide)** - This is a strong base used to deprotonate the diketone, likely forming an enolate ion as an intermediate. 2. **(CH₃)₃SiCl (Trimethylsilyl chloride)** - This reagent is often utilized to protect or modify functional groups. It reacts with the enolate intermediate. 3. **(CH₃)₃CCl (Tert-butyl chloride)** in the presence of **ZnCl₂ (Zinc chloride)** - This combination suggests a Friedel-Crafts reaction, likely introducing a tert-butyl group onto the ring. **Options for the Major Product:** a. A six-membered ring with a tert-butyl group and two ketone groups. b. A six-membered ring with two ketone groups and no additional substituents. c. A six-membered ring with an isolated double bond, one ketone group, and a tert-butyl group. d. A six-membered ring with two ketone groups and a tert-butyl group attached at a different position from option a. e. None of the above (not a.-d.). The illustration presents potential structural outcomes from the reaction steps. Each option depicts variations in substituent positions and connectivity on the cyclic diketone structure after the reaction sequence, assessing possible regioselectivity and stereochemistry of the reaction.
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