Juntsey 10.3 THE STEREOCHEMICAL OUTCOME OF AN E2 The examples in the previous section focused on regiochemistry. We will now focus our atter an E2 reaction with the following substrate: performing Br sands olier sasille eno vino 155qxs sw zi ludTavirosl Cadt naiwer drived on case. This substrate has two identical ß positions so regiochemistry is not an issue in this same result. But in this case, stereochemistry is relevant, because two stereoisomeric alke M Hofmann EtO Br Major

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How do we know if the trans predominants over the cis? Or is it a given?

10.3 THE STEREOCHEMICAL OUTCOME OF AN E2 REACTION
The examples in the previous section focused on regiochemistry. We will now focus our attention on stereochemistry. For example, consider
performing an E2 reaction with the following substrate:
Br
asri Torlich snells ono vino baas w
... eniwerb yo
ned) todist
This substrate has two identical ß positions so regiochemistry is not an issue in this case. Deprotonation of either ß position produces the
same result. But in this case, stereochemistry is relevant, because two stereoisomeric alkenes are possible:
SM
Hofmann
Eto
Br
Major
91
moiqsaxs vasm woH
in bomohsq ai ovo
+
Minor
Transcribed Image Text:10.3 THE STEREOCHEMICAL OUTCOME OF AN E2 REACTION The examples in the previous section focused on regiochemistry. We will now focus our attention on stereochemistry. For example, consider performing an E2 reaction with the following substrate: Br asri Torlich snells ono vino baas w ... eniwerb yo ned) todist This substrate has two identical ß positions so regiochemistry is not an issue in this case. Deprotonation of either ß position produces the same result. But in this case, stereochemistry is relevant, because two stereoisomeric alkenes are possible: SM Hofmann Eto Br Major 91 moiqsaxs vasm woH in bomohsq ai ovo + Minor
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