Januvia is the trade name for sitagliptin, a drug that increases the body's ability to lower blood sugar levels, and thus it was introduced in 2006 for the treatment of type 2 diabetes. (a) Explain why the five-membered ring in sitagliptin is aromatic. (b) Determine the hybridization of each N atom. (c) In what type of orbital does the lone pair on each N atom reside? noifosen noitsnimile roso to CF3 ubong at weyd N. HO .N. N. NH2 Ô mo lanolhutdanoo odi wad to taa riosa tiw bolcod es eene onwoll HO O bomy wollct H8 S o02.0H]ainageen sitagliptin

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Chapter1: Chemical Foundations
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Januvia is the trade name for sitagliptin, a drug that increases the body's ability to lower blood
sugar levels, and thus it was introduced in 2006 for the treatment of type 2 diabetes. (a) Explain
why the five-membered ring in sitagliptin is aromatic. (b) Determine the hybridization of each N
atom. (c) In what type of orbital does the lone pair on each N atom reside?
snimile rios
CF3
02.H
N.
ng art wed
HO
NH2 0
F
to tea roso iw bolcot es eene onwll
wbomolhemoa lanothutianoo ori wad
sitagliptin
CH CH OH H eo
OHE
1OM8 w bnod elduob s of bebbs s1s 10 bns 18 lo alnemela erIT
g--yrtem-S as doue enexic lsohtemmyanu bns nedw bemot
Ishslam
Transcribed Image Text:Januvia is the trade name for sitagliptin, a drug that increases the body's ability to lower blood sugar levels, and thus it was introduced in 2006 for the treatment of type 2 diabetes. (a) Explain why the five-membered ring in sitagliptin is aromatic. (b) Determine the hybridization of each N atom. (c) In what type of orbital does the lone pair on each N atom reside? snimile rios CF3 02.H N. ng art wed HO NH2 0 F to tea roso iw bolcot es eene onwll wbomolhemoa lanothutianoo ori wad sitagliptin CH CH OH H eo OHE 1OM8 w bnod elduob s of bebbs s1s 10 bns 18 lo alnemela erIT g--yrtem-S as doue enexic lsohtemmyanu bns nedw bemot Ishslam
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