Is tricellular junction important in cell junction specification?
https://en.wikipedia.org/wiki/Cell_junction#:~:text=Cell%20junctions%20(or%20intercellular%20bridges,the%20extracellular%20matrix%20in%20animals.
Epithelial cells are polarized and they form apical cell–cell junctions between adjacent cells, which are composed of tight junctions (TJs), adherens junctions (AJs), and desmosomes and AJs and septate junctions (SJs).
In epithelial sheets, where cells are packed two-dimensionally, there are many points where three cells meet. These points are called tricellular contacts.
Tricellular junctions(TCJs) are core structures of epithelial tissues. They are critical for tissue barrier functions in numerous tissues.
TCJ channels, or pores, are present along the apical-basal axis at the contact interfaces between three cells. They are formed by a series of stacked diaphragms, tricellular channel diaphragms (TCD).
Tricellular junctions differed greatly from epithelial cells: two of the endothelial cells form a bicellular junction with no overlying edges, creating an intercellular cleft, while the third cell, termed the ‘flap’ cell, overlies the bicellular junction.
Tricellular junctions control permeability by allowing large macromolecules to pass and that they can open and close.
Tricellular junctions might form part of the large pore, they are important for the maintenance of barrier function,
At tricellular contacts, cell-cell junctions take on specialized organizations referred to as tricellular junctions, including tricellular TJs (tTJs), tricellular AJs (tAJs), and tricellular SJs (tSJs).
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