In what disease is a decrease in sphingomyelin observed?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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In what disease is a decrease in sphingomyelin observed?
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Sphingomyelin, type of sphingolipid found in the cell membrane of animal cells, especially in the myelin sheath that surrounds nerve cell axons. Sphingomyelin consists of a phosphocholine head group, sphingosine, and fatty acid and not from the glycerol head group. This composition of sphingomyelin plays important roles such as synthesis and degradation to produce secondary messengers in signaling pathways. These are synthesized involves the enzymatic transfer of phosphocholine from phosphatidylcholine to ceramide.
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